Loading presentation...

Present Remotely

Send the link below via email or IM


Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.



on Fibrodysplasia ossificans progressiva

Magpie Catso

on 19 April 2010

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of FOP

Fibrodysplasia Ossificans Progressiva (FOP for short) What is it? FOP is an extremely rare disease where muscles, tendons, and ligaments literally turn to bone when they are damaged. This is because there is a mutation in the body's repair system, and when the extra bone is surgically removed, the bones grow back. What Are the Symptoms? •Short toe
•Bone fusion in toe
•Short thumb
•Swellings in fibrous tissue
•Swellings in aponeuroses , fasciae, tendons
•Progressive fusion of neck vertebrae
•Muscle ossification
•Fibrous tissue ossification
•Restricted arm, joint, knew, wrist, shoulder, spine, neck mobility
•Mutations in the body’s repair system
•Genes mutate for no apparent reason
•A small amount of cases are inherited from a parent who has FOP
•Sometimes hereditary
What Causes FOP? This is the skeleton of a person with FOP. Extra bones replace muscles. This is how you pronounce fibrodysplasia ossificans progressiva. fibro-dis-play-sha os-sih-fih-cans pro-gress-ev-a What does it do to the body? •Bone replaces fasciae, tendons, ligaments
•Affects the neck, spine, chest, shoulders, elbows, wrists, hips, knees, ankles, jaw, and many areas in between.
•Tends to occur in the neck, shoulders and the upper back early in life and in the hips and knees during adolescence or early adulthood.
•Bumps or injuries cause flare-ups and speeds up bone growth
•Surgeries to remove bone make condition worsen. Bones “repair” themselves with even more bone
•A flare-up occurs when the body starts to generate new bone. Leads to tissue swelling and discomfort.
•Sometimes people can go months or years without a flare-up
•Some people have very severe movement restriction. Others may have some range of motion.
•Creates “second skeleton” that traps the body
The malformed big toe is a very common symptom of FOP. This is the skeleton of Harry Eastlack. He lived with FOP until he died before his fortieth birthday. He gave his body to his physician, who danated his skeleton to the Mutter Museum. What research is being done? •University of Pennsylvania School of Medicine, is the only laboratory in the US dedicated to FOP research
•Funds spent on research - Approx. $1.5 million/year-
75% from FOP family fundraising and donations
25% from institutional support (NIH/NIAMS, Orthopaedic Research and Education Foundation)
University of Pennsylvania School of Medicine logo.
Full transcript