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Amyotrophic Lateral Sclerosis

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Aubrey Loria

on 21 January 2014

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Transcript of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
The Brain-Map by Likhita and Aubrey
copy and paste as needed and take advantage of an infinite canvas!
Upper and Lower Motor Neuron Disease
Other Names:
A Few Fancy Words
Amyotrophic: "No muscle nourishment"
Sclerosis: hardening of muscle tissue

Atrophy: Muscles waste away because the motor nerve cells are damaged
9 in 10 cases no identifiable cause
Genetic: 5% of cases have genetic background
-Defects in gene that produces SOD1 enzyme

Loss of muscle strength
Coordination gets worse
Breathing, Swallowing may be first affected
Head drooping, muscle cramps, paralysis, speech issues, weight loss
Progressive- Death when respiratory muscles no longer stimulated or with infection

What is ALS?
ALS is an incurable degenerative motor neuron disorder
Lab Tests: Urine, blood & thyroid functioning tests
Muscle and/or nerve biopsy
CSF analysis, X-rays, MRIs
Electrodiagnostic- electrodes record muscle and nerve responses
NO actual cure!
Physical therapy, rehabilitation, use of wheelchair/braces
Nutritionist- to help keep muscle mass -gastrostomy- tube in belly for feeding
-Riluzole slows symptoms
-Baclofen/diazepam control muscle rigidness with everyday activities
Clinical Trials
Interesting Facts
Not contaigous
5,600 people diagnosed yearly
2 deaths per 100,000- affects 30,000 in US
20% live 5+ years, 10% 10+ years, 5% 20+ years
Occurs internationally, no boundries (racial, ethnic...)
Common among 40-70 year old (mostly 60+)
Steve Gleason

One Sweet World Foundation,
Team Gleason
Video now!
we learned from these people:

"Amyotrophic Lateral Sclerosis (ALS) Fact Sheet." :
National Institute of Neurological Disorders and Stroke (NINDS)
. Usa.gov, n.d. Web. 19 Jan. 2014.
"ALS - Amyotrophic Lateral Sclerosis."
ALS, Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
. John Hopkins Hospital System, n.d. Web. 19 Jan. 2014.
"Amyotrophic Lateral Sclerosis."
New York Times.
The New York Times Company, n.d. Web. 19 Jan. 2014.
"Facts You Should Know." -
The ALS Association
. Convio, n.d. Web. 19 Jan. 2014.
"Amyotrophic Lateral Sclerosis (ALS)."
Amyotrophic Lateral Sclerosis (ALS)
. RSS Feeds, n.d. Web. 19 Jan. 2014.
"Center for ALS."
Center for ALS
. Emory University, n.d. Web. 20 Jan. 2014.
"Amyotrophic Lateral Sclerosis (ALS)." - The University of Chicago Medicine. University of Chicago Medical Center, n.d. Web. 18 Jan. 2014.
"Lou Gehrig's Disease (ALS)." KidsHealth. Ed. Steven Dowshen. The Nemours Foundation, 01 Jan. 2013. Web. 19 Jan. 2014.
Stephen Hawking. Digital image.
Super Stars of Science
. N.p., n.d. Web. 19 Jan. 2014.
Young Stephen Hawking. Digital image. Tumblr. N.p., n.d. Web. 19 Jan. 2014.
Motor Systems. Digital image. The Health Success Site. N.p., n.d. Web. 20 Jan. 2014.
Steve Gleason Photo. Digital image. The Hollywood Gossip. N.p., n.d. Web. 20 Jan. 2014.
Link: https://www.youtube/watch?v=uDAKAPR-b1E
Classical/Sporadic- occur randomly
Familial- inherited from family
PBP- affects chewing, swallowing, speaking
PMA- JUST lower motor neurons can be affected
Lucie BruijnPh. D. - Cheif Scientist of the ALS Association
1) Do you directly interact with patients? What is the most common issue with your patients? I run the research program so interact with patients only at educational forums. Challenges for patients includes lack of therapies that change the course of the disease, speech and swallowing so difficult to eat and communicate if they have the bulbar form of ALS, mobility issues if they have limb onset. Challenges to maintain their job, interact with their children, dress themselves, shave brush their teeth.
2) How do you diagnose someone with ALS? Is there a way to be 100% sure that your diagnosis is correct? There are a series of clinical tests that are done, many to exclude other diseases that can look similar. For the very typical ALS and when diagnosed by an expert Neurologist familiar with ALS diagnosis is usually always correct but this is not true for people diagnosed by their general practicioner. There is no single test like a blood test to confirm ALS
3) Do you have any success stories regarding patients? Not in terms of recovery from their disease but many heroic examples of what patients do for each other to support and further research efforts
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