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Mitochondrial Theory of Aging

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by

Amar A

on 5 May 2015

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Transcript of Mitochondrial Theory of Aging

Mitochondria
mitochondria are the cell's main source of reactive oxygen species
the ROS react with mitochindria's macromolecules.
Super Oxide Formation
Superoxide dismutase
Effects of UV light
degradation of H2O2


H2O2 2HO.
The Free Radical Theory
of Aging

A visious cycle
What Are Free Radicals
a radical or free radical is an atom or molecule with an unpaired electron
Common free radicals produced in the human body
Free Radical and Aging
Cells continuously produce free radicals by normal metabolism and oxidation of organic compounds and these free radicals damage cellular macromolecules and due accumulation of these damage over time period cause aging
these species are unstable and react readily with a wide variety of compounds
radical reactions are chain reactions
mtDNA
damage
more ROS
decreased
mitochondrial
function
Super Oxide Reactivity
O2-+NO ONOO-
nitric oxide function :
relaxes vascular smooth muscles and reduces blood pressure.
Acts as a Neurotransmitter
Immune response
Nitration

Consequences
Peroxynitrite and nitrogen dioxide inhibit protien P53
Aging and Oxidation Protection Mechanism:
Telomerase
Full transcript