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Longevity Aegon 2017 10

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Raymond McCauley

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Transcript of Longevity Aegon 2017 10

+1-650-776-4561
for your attention
Raymond McCauley
biochemistry
biophysics
electrical engineering
computer science
bioinformatics
nanotechnology
genetic engineering
DNA sequencing
personalized health
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
systems
biology
past:
Biotech Chair: Singularity U
Co-Founder: Playtpus Project
Co-Founder & Chief Architect: BioCurious
Principal: Exponential Biosciences

Current Research Areas:
Personal Genomics
Therapeutic Genetic Engineering
Low Cost Access to Biotech Tools
Cancer Dx and Treatment
Singularity
University
Raymond McCauley
@raymondmccauley
Thank you
Raymond McCauley
The Business of Longevity
raymond@singularityu.org
+1-650-776-4561
http://rockhealth.com/tag/wearables/
One More Thing...
from being in
an exponential business
Find an exponential trend,
then hitchhike
A prototype beats a plan
Product Development Process (PDP)
typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk
Nothing fades faster than last year's technology
2008
$500K
2012
$1
People
Teams
Interdisciplinary
Disruption
is never
Expected
Salim Ismail
Add a specialty
Be half of a team
Assemble a varied team
Find translators
Develop internal people
Innovation Lessons
Triple Major?
Design Your Own Major?
Makes vaccines using mRNA from diseases
"Vaccinated with information"
Gates Foundation invests $57M
"Cellular scissors chop up HIV virus"
Salk Institute
Nature Communications "Use of the CRISPR/​Cas9 system as an intracellular defense against HIV-1 infection in human cells", Liao et al
23andMe and Apple
enter drug research business
"crowd-sourced clinical trials"
Apple ResearchKit
- Asthma
- Parkinson's Disease
- Breast Cancer
- Diabetes
- Cardiovascular
Enrolled 7400+ people in 24 hours.
Previous largest study was 1700.
Live Longer or Die Trying
advisor,
consultant,
investor
People who never got:
cancer
cardiovascular disease
neurological conditions
Q: Secret to live a long time?
A: Pick good parents!
Implants are Easy and Coming Soon
Biosensing
and
Command & Control
Biosensing implants in development
blood sugar
blood chemistry
temperature, blood pressure, ECG
heart attack, stroke early warning
Longevity
Squaring the
Survival Curve
Limit at 120, for a while
Overpopulation? No
Proposal: Longevity Lab
Cell
Repair
Technologies
Accidental death
by 192
on average
Pensions & Advanced Health Accounts
It Varies, by Disease & Country
Hans Rosling's
Gapminder
Life Expectancy +29.2 years

Deaths in ages 0-5
1900: 30.4%
2000: 1.9%
Sanitation
Water
Access to
Antibiotics
Death Be Not Proud, Part 1
What We
Die From
Beyond 120?
Death is not a Democrat
I intend to live forever. So far, so good. ~Steven Wright
Life Expectancy +25

Deaths in ages 85-110
2000: ~50%
2030: ~10%
Death Be Not Proud, Part 2
Genome Project Dividend
Worldwide Infectious Disease
Extend Healthspan
cancer
cardiovascular disease
neurological conditions
Autoimmune, Affluence
Health Surveillance
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Genetic engineering
Stem cell therapy
Melanoma repair
DNA cross-checking
DNA repair
DNA
Cryonic recovery
Cell reprogramming
Death Be Not Proud, Part 3
Cryonics for
Organ Replacement
Organ Preservation Alliance
DNA
Nanobots
Stem
Cell Tx
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behavior Change
Underestimate Savings Need
Health Care Cost Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
Longevity Escape Velocity
+ 3.0 months / year
+ 2.5 months / year
120
0
5
80
Age
% Pop
Longevity Curve
120
0
5
80
Age
% Pop
Longevity Curve
Quantified Self
Biosensors
Notes:

3 things that are different -- writing / drive / coding
communicable disease / cryonics /

unsatisfying

heterochronic parabiosis
FMD

3 real things -
stop smoking (and other substance abuse)
weight control ---
schedule health maintenance HOMEWORK


hacker's diet / try - test - modify

practical
testing
diets


pyramid

Add Survival Curves, years to different death thing
Add references to money pieces (& add money figures)
SHow how actuarial curves are always wrong
Call new tech "deal breakers" "disruptions"
Discuss Longevity Escape Velocity as a Moore's law -- driven by economics
Ray Kurzweil prediction: +1 year / year by 2029
- 19 April 2016, "Reinvent Yourself: The Playboy Interview with Ray Kurzweil"
Jane Doe
Female, 36, Non-smoker, BMI=19
Scenario 2: Deny Coverage
Chilling effect on life-saving genetic testing
Scenario 1: Ignore Genetic Tests
Alzheimers, Familial Cancer High Risk, ...
Personal Genetic Testing
Breaks Insurance
Patient's finding long-term care issues
5X more likely to buy long-term policy
- Dr. Green, Brigham and Women's Hospital, Personal Communication
Legal backlash
Oregon, Vermont - ban genetics use in life insurance
California, Texas, New York, US - next?
25% of test refusers: fear
life insurance discrimination
But BRCA1-positive
~60% breast cancer risk
versus ~12% general risk
Scenario 3: Be the Solution
Genetic Test,
BUT
Hold Premiums Steady
Encourage clients to screen, take action
Preventive measures = Risk drops 87% to 5%
Genetic Testing
and Insurance
"DNA methylation-based biomarkers, often referred to
as 'epigenetic age' or 'epigenetic clock', are robust
estimators of chronological age of an individual..."
Life Epigenetics, Inc. & "DNA Age"
Bad News for Insurance
Regulation to restrict use of
genetic testing for inborn traits
to set premiums or deny coverage.
Good News for Insurance
genetic testing for acquired traits

but first...
Aubrey
de Grey
Chief Science Officer
SENS Research Foundation
Longevity
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behaviors Change
Underestimate Savings Need
Health Care Costs Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
the Longevity Dividend
+ 3.0 months / year
+ 2.5 months / year
Radical Biotechnology
& Fintech
Old Institutions Break
Insurance
Pensions
Retirement
Social Security
people aged 50+ equal
a global market nearly the size of China
Longevity Escape Velocity
current progress towards
}
demographics shift
Biohacker
Hannes Sjöblad
Body Hacker
Chief Disruption Officer at Innovation Hub Epicenter
Faculty SingularityU Denmark
At 50
first colonoscopy
,
then every 5-10 years
(more or earlier if higher risk)
Every Year
blood pressure (or more)
flu shot
mammogram (monthly self exam)
dermatology screening
eye exam (age 55+, every 2 years before)

Every 3 Years (at least)
cholesterol profile + fasting blood sugar test
pelvic exam / pap smear / HPV test (ages 30-65)
At 50
first prostate exam
,
then every year
(earlier if higher risk)
THIS IS YOUR HOMEWORK - PUT IN ON YOUR CALENDAR
Schedule Health Maintenance
Might Not Hurt / As Needed
Vitamin Supplements
Weight Record - Daily or Weekly
Cholesterol Particle Size Test
VAP Test, VAP Diagnostics
Lipoprotein Particle Profile (LPP) Test, SpectraCell
NMR LipoProfile Test, LabCorp
Cardio IQ Report, Quest Diagnostics
Body Scan
Low-Dose Aspirin
Genetic Scans
Cholesterol Particle Size Tests
Pharmacogenomics
Nutrigenomics
Clinical Genomics (ACMG)
Stop Smoking
Lose Weight
Exercise Regularly
Internet-connected Scales
MD weight loss programs
FMD - fast mimicking diets
cognitive behavioral therapy (CBT)
personalized
evidence-based
gamified
QuitGenius
Nutrigenomics
(Prolon?)
counseling
+ drugs
+ measure/record
nutrients
carb & fat metabolism
food sensitivities
behaviors
Heterochronic
Parabiosis
Caloric
Restriction
"The Big
Green
Button"
Problem
Courtesy: Stanford Young Blood Institute
only two things
proven
to
increase lifespan in mammals
if
we get to the end of the presentation
I'll show you two ways to
potentially
harness these effects
& Apology
"A [questionable] startup called Ambrosia will fill your veins with the blood of young people and empty your pockets of $8,000."
- MIT Tech Review, Jan 2017
Ambrosia
www.ambrosiaplasma.com
3 Things
To Do Now
Microbiome Scan
$999 genome sequencing
+ interpretation
$199 BRCA testing
+ interpretation
+ counseling
+ updates
$29 superhero testing
+ scans variants for
strength
intelligence
speed
+ counseling
+ cape
for qualifying
individuals
veritasgenetics.com
getcolor.com
orig3n.com
genomics
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behaviors Change
Underestimate Savings Need
Health Care Costs Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
the Longevity Dividend
+ 3.0 months / year
+ 2.5 months / year
Radical Biotechnology
& Fintech
Old Institutions Break
Insurance
Pensions
Retirement
Social Security
people aged 50+ equal
a global market nearly the size of China
Longevity Escape Velocity
current progress towards
}
demographics shift
Ray Kurzweil prediction: +1 year / year by 2029
- 19 April 2016, "Reinvent Yourself: The Playboy Interview with Ray Kurzweil"
& a Caveat
Full transcript