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Transcript of The DNA
-the hereditary material or
molecule whose building
block sequence encodes the
information that a cell uses to
construct a particular protein
-most DNA is located in the cell nucleus
-a small amount of DNA can also be
found in the mitochondria
Where is the DNA?
Johann Friedrich Miescher
In 1869, a Swiss student
of cell metabolism who analyzed the materials in the nuclei of white blood cells and sperm cells
-He discovered a material
associated with protein and
phosphorus where he called
the material as
In 1928, he experimented on two strains of bacterium Streptococcus pneumonia
They managed to remove the DNA from the S strain bacteria and incorporated in the R stain. Inside the R strain cell, the DNA of the S strain caused the R strain to develop capsules. The R strain even passed on the genetic information of the S strain DNA to the offspring.
They identified DNA as the genetic material.
In 1953, they discovered the structure
of DNA which is a double helix
resembling a spiral ladder or staircase
-the basic building units/structures
of nucleic acid
Each nucleotide contains:
five-carbon sugar (deoxyribose)
- thymine & cytosine
- adenine & guanine
Complementary Base Pairing
Adenine to Thymine
Guanine to Cytosine
Erwin Chargaff, an American biochemist
amount of guanine (G) is always equal to the amount of cytosine (C)
amount of adenine (A) is always equal to the amount of thymine (T)
blueprint of life
storage of information
ability to pass hereditary traits
MR. ROMMEL D. LLANILLO
- he injected the live R bacteria cells into the mice
and the mice lived.
- he injected the live S bacteria cells into the mice
and mice died.
- he killed the harmful S cells with extreme heat,
and then injected the dead S cells into the mice and
the mice lived
- he added live R cell (which are harmless) to the
already dead heat-killed S cells, and then injected it
into the mice, but the mice died.
Oswald Avery, Colen MacLeod & Maclyn McCarty
They identified the DNA
as a genetic material