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P53 Tumor Suppressor Gene

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collin gilbert

on 17 March 2015

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Transcript of P53 Tumor Suppressor Gene

P53 is a tumor suppressor gene because it combats tumorigenesis (tumor growth) through regulation of the cell cycle and calculated apoptosis (cell death).
A. Classification
P53 Gene
P53: Regulates Cell Birth, Cellular Growth, and apoptosis (Promotes or inhibits depending on the circumstances).

Sections affected: G1 (puts into G0), G2, and M
B. Normal Function
One amino acid in the gene is altered, and this causes it to no longer be able to bind to DNA and regulate cell growth/division.

Allows uncontolled cell growth and division and some of the DNA that is passed on contains mutations.
C. Mutated Gene
Colon, Breast, Lung, Bladder, Pancreas, Brain, Stomach, Oesophagus,Cervix, Liver, Lymphomas, Neuroblastomas, head and neck squamous cell carcinoma, and many more that are way too complicated to be pronounced.
D. Types of cancers
P53's home is the 17th chromosome
E. Chromosome Home
Must originally come from a miscoding made by cells during the cell cycle (purely random chance). Environmental factors are suspected to play a part in this, but information about this is vague.

Once the gene has mutated it can be passed on to offspring (Must have two damaged copies). Can inherit breast cancer or Li-Fraumeni Syn.
F. Mutation Causes
Carcinogenesis: Multistage Process tht involves the activation of oncogene and inactivation of tumor suppressor genes (p53)

Studies are being done learn how to fix mutated p53 genes through mutating another suppressor protein.
G. Treatments/ Studies
Website: http://www.nature.com/scitable/topicpage/p53-the-most-frequently-altered-gene-in-14192717

Article: http://www.sciencedaily.com/releases/2014/03/140324104318.htm

Video:
Works Cited
Collin and Dakota W.
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Full transcript