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Communication between Neurons

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by

Jason Whetten

on 2 February 2017

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Transcript of Communication between Neurons

The Synapse
Communication between Neurons
Receptor Activation
Two Classes
Postsynaptic Potentials
EPSP or IPSP
Then what happens
Autoreceptors
After Release...
Jason Whetten
Information travels via chemicals across the synapse
Chemicals (Neurotransmitters) produce post synaptic potentials
Ligand
Structure
Axodendritic
Axosomatic
Axoaxonic
Release of
Neurotransmitters
Action Potential
NT Release
1. Vesicles dock against the membrane due to proteins binding with presynaptic membrane
2. Action Potential opens Ca++ Channels
3. Ca++ enters the cell
4. Ca++ binds to proteins and cause them to open
5. Neurotransmitter is released
Three Pools of Vesicles
Release Ready
Recycling Pool
Reserve Pool
< 1%
10 - 15%
80-90%
Rate of Firing
Kiss and Run
Merge and Recycle
Bulk Endocytosis
Ionotropic
Metabotropic
Excitatory Postsynaptic Potential (EPSP)
Inhibitory Postsynaptic Potential (IPSP)
Na+ Receptor
K+ Receptor
Cl- Receptor
Ca++ Receptors
Change Structure in Postsynaptic Cell
Neural Integration
Excitatory Neurons
Inhibitory Neurons
Actively sending action potentials down the axon
Act as regulators by stopping information flow
Reuptake
Enzymatic Deactivation
Axoaxonic Synapse
Gap Junction
ACTIVITY
Pre-synaptic and Post-synaptic
Metabotropic
Second Messenger
Full transcript