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Senior Seminar Presentation: Epigenetic Modifications and Obesity Outcomes
Transcript of Senior Seminar Presentation: Epigenetic Modifications and Obesity Outcomes
To determine which genes are involved in influencing obesity development by epigenetic mechanisms to predict susceptibility to obesity and develop theraputic treatment approaches. Epigenetics:
the study of heritable changes in gene expression that occur in the absence of a change in the DNA sequence itself. Mechanisms of Epigenetics DNA Methylation Covalent Modification of Histones DNA Packaging around Nucleosomes Chromatin Folding Chromatin Attachment
to Nuclear Matrix The Idea:
Epigenetic changes to the promoter region of epiobsigenes, such as tumor necrosis factor gene, leads to obesity. A low calorie diet should be able to lower epigenetic abnormalities. Why?
By taking in the right supplements, the epigenome will self correct. This self correction to the epigenome generally includes corrections to epiobsigene regulators. If regulators are not functioning properly, disease may ensue. The Experiment:
Groups were fed diets with a different dietary or nutritional condition. The effects on gene expression were then recorded. What It All Means:
The data strongly suggests that epigenetic mechanisms may be boosted or impaired by dietary factors in the mother and could be involved in obesity susceptibility in the offspring. In the adult state, examples of diet induced epigenetic changes have also been reported. Vegetarian Diet:
Three fold increase in manganese superoxide dismutase expression. - Isoﬂavone genistein
- Tea polyphenols
- Garlic’s diallyl disulﬁde Julia Jennings