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Copy of Bio-interfacing
Transcript of Copy of Bio-interfacing
As emerging technologies interact with society, certain individuals would be benefited more than others. The following are the impacts that the applications of bio-interfacing has on the society.
Basic characteristics of a biosensor
Biosensors are classified either by their
Application of Biosensor
High through-put technique,sensitive accurate and easy to use
Highly specific,fast and cost effective
Multiple residues analyzed in one shot ( as many as chips in an array)
Allow rapid continuous control on -line monitoring
Less labor intensive
Full automation: higher productivity
Expensive equipments hard to construct
Analysis restricted to available chips
Intoxication of the sensor cells by other molecules that diffuse or deposit on the membrane
What is Biosensor ?
History of Biosensor
Classification of Biosensor
Types of transducers
Advantage and Disadvantages
What is biosensor?
A biosensor is a device for the detection of an analyte that combines a biological component with a physicochemical detector component.
Various biosensor research and the use of nanotechnology
This video reinforces the research and applications of biosensors as well as the role nanotechnology plays
Melab. (2009). Schematic configuration of a Biosensor [Photograph]. Retrieved on January 15, 2014 from melba.snu.ac.kr/
N.a. (2006). Lecture 17: Biosensors. Retrieved on January 25, 2014 from ocw.mit.edu/
Nanobioengineering and Bioelectrics Lab. (2010, April 8). Biosensor, Nanobiosensor, Bioelectronics, FIU. [Video]. Retrieved on January 26, 2014 from www.youtube.com/
News Medical. (n.d.). Biosensors – What are Biosensors?.News Medical.Retrieved on January 10, 2014 from www.news-medical.net/
Worldcarfans. (2009). Honda Develops Brain-Machine Interface Technology [Video]. Japan: Youtube. Retrieved on January 21, 2014 from www.youtube.com/
Father of the Bio sensor
1916 First report on immobilization of proteins
1922 First glass pH electrode
1956 Clark published his definitive paper on the oxygen electrode.
1962 First description of a biosensor: an amperometric enzyme electrodre for glucose (Clark)
1975 First microbe based biosensor, First immunosensor
1982 First fibre optic-based biosensor for glucose
1998 Blood glucose biosensor launch by LifeScan FastTake
Surface Plasmon resonance
Professor Leland C Clark Jnr 1918–2005
History of Biosensor
The four main types of transducers used in biosensors are:
Surface acoustic wave sensors
Detects the hCG protein in urine
The level of volatile organic compounds in air
monitoring the production of alcohol during the fermentation
Quartz Crystal Microbalance
Glucose monitoring device (for diabetes patients)
Monitors the glucose level in the blood.
to detect 24 pathogens(anthrax,plague,smallpox...)
to detect the presence of poisonous or explosive gases in mines
Market size of Biosensor
This image shows the components of a biosensor and the way it works
Ion-selective field effect transistor
Solid electrolyte gas sensor
$7.3 billion in 2003
$10.2 billion in 2007
This becoming one of the fastest growing sectors in the world
to detect specific genes or parts of genes
is a type of chemical sensor that mesured as the potential difference between the working electrode and the reference electrode
measures current generated by electrochemical oxidation oreduction of electroactive species at a constant applied potential
Ion selective electrodes (ISE)
converts the activity of a specific ion dissolved in a solution into an electrical potential which can be mesured by a voltmeter or pH meter
Ion selective field effect transistor (ISFET)
used for measuring ion concentrations in solution; when the ion concentration (such as H+, see pH scale) changes, the current through the transistor will change accordingly.
These involve determining
changes in light absorption between the reactants and products of a reaction,or measuring the light output by a luminescent process
is an optical detection rocess that occurs when a polarized light hits a prism covered by a thin metal layer
Luminescence is emission of light by a substance not resulting from heat
is a device that uses the piezoelectric effect,to measure changes in pressure acceleration , strain or force by converting them to an electrical charge
are class of microelectromechanical system which rely on the modulation of surface acoustic waves to sense a physical phenomenon
can detect changes in frequency of the crystal due to changes in mass on the surface of the crystal
Detect changes in temperature
The temperature changes are usually determined by means of thermistors at the entrance and exit of small packed bed columns containing immobilised enzymes within a constant temperature environment
Maximum linear value of the sensor calibration curve. Linearity of the sensor must be high for the detection of high substrate concentration.
The value of the electrode response per
Interference of chemicals must be
minimized for obtaining the correct result
The necessary time for having 95%
of the response.
Drinking water security
Detection of food pathogens quick and easy
to detect drugs or explosives in airport
A biosensor should be specific to e analyte which it interact