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Epidermodysplasia verruciformis

Treeman Disease for Biology class

Sebastian Bowerson

on 5 May 2010

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Transcript of Epidermodysplasia verruciformis

Double click anywhere & add an idea Epidermodysplasia verruciformis
(Treeman Disease)
The condition usually has an onset of between the ages of 1–20, but can occasionally be present in middle-age. The cause of the condition is an inactivating mutation in either the EVER1 or EVER2 genes, which are located adjacent to one another on chromosome 17. The Treeman with his father next to him before Surgery After surgery by a team of local doctors who performed eight major operations on Dede, involving an electric saw, skin grafting and the removal of pounds of dead skin tissue hardened by the years that he's had this condition. Extremely rare autosomal recessive genetic hereditary skin disorder associated with a high risk of carcinoma of the skin. Patients present with
flat, slightly scaly, red-brown macules on the face, neck and body
verruca-like papillomatous lesions, seborrheic keratosis-like lesions, and pinkish-red plane papules on the hands, upper and lower extremities, and face.

The benign form of EV presents with only flat, wart-like lesions over the body, whereas the malignant form shows a higher rate of polymorphic skin lesions and development of multiple cutaneous tumors.

On 26 August 2008, Dede returned home following surgery to remove 6 kg (13 lb) of warts from his body A totally effective treatment method against EV has not yet been found. Several treatments have been suggested, and acitretin 0.5–1 mg/day for 6 months’ duration is the most effective treatment

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