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Sleeping Sickness Parasite

Dara Banna

on 13 October 2012

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Transcript of Trypanosoma

Trypanosoma Species Sleeping Sickness Parasite Introduction Classification Morphology Why is Trypanosomiasis so deadly? References Trypanosoma brucei is a protozoan with flagella (protist) species that causes African trypanosomiasis (or sleeping sickness) in humans and nagana in animals in Africa. There are 3 sub-species of T. brucei: T. b. brucei, T. b. gambiense and T. b. rhodesiense. Kingdom:Protista
Species:T. brucei Trypanosomes are highly susceptible to antibodies and complement
They live fully exposed to antibodies in the blood stream
They induce a very strong antibody response
Still they manage to thrive in the same host for a year or longer, until the host dies Midical Microbiology 24th Edition , Jawetz Melnick & Adelberg's
Atlas Of Medical Helminthology and Protozology 2nd edition, Jeffrey & Leach
Encyclopedia Britannica
Dr.T.V.Rao MD for Medical and Health Care Workers
Wikipedia Route of Transmission
Life Cycle Infection is characterized by periodic waves of Parasitemia

Each wave represents a single antigenically distinct clone or serotype
Antibodies produced in the first week against clone A will not react with clone B
The changing display of different antigens is called antigenic variation
Antigenic variation is an important form of immune evasion
Do You Have any Questions ? YES ? I don't know ?
Just Google it ;) BY Dara Banna & Hunar Rebwar
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