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Myelopoiesis

Presentation for Hematology
by

Christopher Coleman

on 13 November 2012

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Transcript of Myelopoiesis

Myelopoiesis By: Victoria Adeboye
&
Christopher Coleman Myelopoiesis Myelopoiesis is the regulated formation and maturation of leukocytes (white blood cells) that are produced in the bone marrow (myeloid cells). Myeloid Cells Neutrophil Eosinophil Myeloid cells include neutrophillic granulocytes, eosinophilic granulocytes, basophilic granulocytes and monocytes. Basophil Monocyte Granulocytes Myelopoiesis All cells in the bone marrow stem from one cell, that cell is called the pluripotent stem cell. Why Myelopoiesis? Why are white blood cells important? DEFENSE!!! White Blood Cells White blood cells act as the defender or army of the body. White blood cells protect the body from infectious diseases and other materials that are foreign to the body via a proccess called phagocytosis. (Leukocytes) Agranulocytes Phagocytosis is the cellular process of engulfing and destroying foreign particles. Neutrophil Band or Stab Size: 9-15 um in diameter

Cytoplasm:
Same as metamyelocyte

Neutral in color
Granules are easily spotted
Few primary granules, many secondary

Nucleus:

Elongated band shape
Chromatin coarse and clumped
Nuclei not visible


12-18% are found mainly in the bone marrow.
If found in the blood, normally a sign of infection Neutrophil Metamyelocyte Size: 10-15 um in diameter.

Cytoplasm:
Moderate – abundant in comparison to nucleus
More neutral in color, between pink and blue
Few non specific granules
Granules are more pink

Nucleus:
Kidney shaped
Coarse and clumped chromatin


15-30% found in the bone marrow. Size: 15-21 um in diameter

Cytoplasm:
Deeply basophilic
Primary granules

Nucleus:
Nucleus to cytoplasm ratio 3:1 – 2:1
Oval or round in shape
Occupies ½ or more of the cell
More coarse chromatin
2-3 nucleoli are visible

2-5% are found in the bone marrow Size: 15-20 um in diameter

Cytoplasm:
Small compared to the nucleus
Moderately blue
No granules

Nucleus:
Occupies 4/5 of the cell
Fine in texture
Round or oval
Red-purple in color
2-5 nucleoli are visible

1-2% are found in the bone marrow. Myeloblast Size: 9-15 um diameter

Cytoplasm:
Abundant amount of cytoplasm
Filled with pink – pinkish purple specific granules
Very few non-specific granules
Color is based off the color of granules

Nucleus:
Segmented into 2-5 lobes which are all attached by thin filaments.
Chromatin is coarse and clumped

3-11% are found in the bone marrow
50-70% are found in the peripheral blood (Mature) Segmented Neutrophil Size: 12-18 um in diameter

Cytoplasm:

Nucleus:
Round, sometimes oval in shape.
Clumped and coarse pattern
Can be located in the center of the cell, or eccentric.

10-20% are found in the bone marrow Neutrophilic Myelocyte Polymorphonuclear Mononuclear Myeloid Maturation As the myeloid cell matures, the cell experiences some morphological changes.
Decrease in cell size
Decrease in nucleus to cytoplasm ratio
Increasingly irregular nuclear shape
Chromatin transition from fine to coarse
Loss of nucleoli
Increase in number of granules
Decrease in color of the cytoplasm Myeloblast The production of a white blood cell takes about 5-7 days 2 4 5 Size: 9 – 15 um in diameter

Cytoplasm:
Filled with large reddish-orange granules

Nucleus:
Usually contains two lobes

Coarse and clumped chromatin pattern

1-5% in the peripheral blood Eosinophil Size: 9 – 15 um diameter

Cytoplasm:
Same as metamyelocyte

Nucleus:
Elongated band shape
Coarse and clumped Eosinophilic Band Size: 12 – 18 um in diameter

Cytoplasm:
Moderate amount cytoplasm to nucleus ration 1:1
Some can contain patches of blue
Non-specific granules range from few to moderate
Specific granules can also be seen
They appear dirty orange and blue

Nucleus:
Oval or round in shape
Clumped and coarse chromatin
Nucleus can be centralized or eccentric Eosinophilic Myelocyte Size: 10 – 15 um in diameter

Cytoplasm:
Moderate – abundant in size
Filled with secondary granules
Granules are bright red and orange in color

Nucleus:
Kidney shaped
Coarse and clumped Eosinophilic Metamyelocyte Size: 9 – 15 um in diameter

Cytoplasm:
Same as metamyelocyte

Nucleus:
Elongated Band shape
Coarse and clumped Basophilic Band Size: 10 – 15 um in diameter

Cytoplasm:
Moderate – abundant
Contains few non-specific granules
Cytoplasm filled with dark purple and black specific granules

Nucleus:
Kidney shaped
Coarse and clumped
Stains dark purple Basophilic Metamyelocyte Size: 10 – 16 um in diameter

Cytoplasm:
Stains colorless or very light pink
Specific granules are stained dark blue


Nucleus:
Usual has two lobes, very seldom contain more
Less coarse than mature eosinophil and neutrophil Basophil Size: 12-18 um in diameter

Cytoplasm:
Moderate amount cytoplasm to nucleus ratio 1:1
Sometimes contain patches of blue
Few specific and non-specific granules
Specific granules are large

Nucleus:
Oval or round in shape
Clumped and coarse chromatin
Nucleus can be centralized or eccentric Basophilic Myelocyte Size: 14 – 20 um in diameter

Cytoplasm:
Very abundant
Blue-grey
Irregular outline similar to jellyfish shape
Ground glass appearance due to azurophilic granules
Vacules may be visible

Nucleus:
Round kidney shape, may be folded upon itself
Fine, lacey chromatin
No nucleoli Monocyte Size: 14 – 18 um in diameter

Cytoplasm:
Blue-Grey in color
Ground glass like appearance
Sometimes contain dust-like azurophillic granules
Ratio compared to nucleus is 3:1 to 2:1
Loose jelly fish like consistency in appearance

Nucleus
Oval shape, may have a fold in it
1-5 nucleoli can be seen
Fine chromatin Promonocyte Size: 12-20 um in diameter

Cytoplasm:
Non granular
Basophillic – blue grey
Cytoplasm to nucleus ratio 4:1 – 3:1

Nucleus:
Oval or round in shape
Purple in color
Fine chromatin
1-2 nucleoli are visible Monoblast Neutrophilic Promyelocyte
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