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Lasse Nørfeldt

on 19 March 2011

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Transcript of Immunology

The process that takes place after infection with a given
pathogen at a specific site Pathogens are in this contex refered to organisms That can be devided into 4 groups The viruses

The bacteria

The fungi

The parasites Wow! That was a lot of information at the same time

Let's take some of it bit by bit. After infection there was mentioned something about phagocytic cells.

It talked about macrophages and neutropils Let's look at the latter Then we had the dendritic cells But how does it recognize the pathogen? All of these 3 cell types are said to belong to the innate immune response But what about The keyword here is also Toll-Like-Receptors (TLR) It then talked about the presentation of pathogen-specific antigens from the dendritic cells to the T-cells in the draining (nearest) lymph node. Let's have a look at that a bit more We then had activation of T-cells Which then activated the B-Cells to make and secrete antibodies.

The soluble antibodies and effector T-Cells then return to the circulation.

They effector T-Cells finds the infection site by a process called "homing". At the infection site some of the effector T-Cells stimulate
the phagocytes to be more effecient.
While others make sure that infected cell die properly
by apoptosis (programmed cell death) so the don't disturb
the surrounding tissue. Kind of like a coach...
..but with biochemicals and
way more complicated The antibodies work in many ways like the complement system

(which might be because it sometimes is involved in it) by sticking

to the surface of the pathogen and "handicap" it.
Which deserves a mention Hope this ( ) gave you the overview of the process that take place after infection with a given
pathogen at a specific site Toll-Like Receptors: Sensors that Detect Infection
By: Peter Christmas (Biology Dept., Radford University) © 2010 Nature Education
Citation: Christmas, P. (2010) Toll-Like Receptors: Sensors that Detect Infection. 3(9):85
http://www.nature.com/scitable/topicpage/toll-like-receptors-sensors-that-detect-infection-14396559# it es
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