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M3 presentatie Orthogonaal Polarisatie Spectrometrie

Bart Groen

on 11 May 2010

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Transcript of OPS

Spiermetabolisme Diabetes Voeding Flow in spierweefsel? Reactie spierweefsel op voeding? Invloed insuline op flow & microvascularisatie? Glycocalyx Interactie tussen diabetes, inspanning, insuline gevoeligheid en perfusie van spierweefsel? Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999;5:1209-12. Glycocalyx
Volume van de intravasculaire glycocalyx Studie populatie 15 gezonde mannen, leeftijd 20 – 30 jaar
15 gezonde mannen, leeftijd 65 – 80 jaar
15 Type 2 Diabetes mellitus patiënten, 65-80 jaar
Leeftijd tussen 20-30 en 65-80
BMI < 30 kg/m2
Non insulin-dependent type II Diabetes Mellitus patiënten (met of zonder medicatie) Exclusie
Hypertensie in VG
Niet DMII gerelateerde medicatie
Alle co-morbiditeiten die interacteren met spier metabolisme
HbA1c > 10.0 % (86 mmol/mol)
Nier- of leverfalen
Obesitas (BMI > 30 kg/m2)
Cardiale of cardiovasculaire VG
DMII gerelateerde complicaties In- en exclusie criteria Uitkomstmaten Secundair:
Postprandiale plasma glucose concentratie
Postprandiale plasma insuline concentratie
Hyperglycemie (glucose concentration > 10 mmol/L, 86 mmol/mol)
Insuline resistentie (OGIS)
Referenties Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994;267:E187-202.
Baron AD. Insulin resistance and vascular function. J Diabetes Complications 2002;16:92-102.
Clark MG. Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle. Am J Physiol Endocrinol Metab 2008;295:E732-50.
Ristagno G, Antonaglia V, Gullo A. Does orthogonal polarization spectral imaging really visualize the "micro"-vasculature? Yes it does! Crit Care Med 2008;36:1689-90; author reply 1690.
Koopman R, van Loon LJ. Aging, exercise, and muscle protein metabolism. J Appl Physiol. 2009;106:2040-8. Epub 2009 Jan 8.
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
Vigilance JE, Reid HL. Glycaemic control influences peripheral blood flow and haemorheological variables in patients with diabetes mellitus. Clin Hemorheol Microcirc 2005;33:337-46.
Nivoit P, Chevrier AM, Lagarde M, Renaudin C, Wiernsperger N. Noninvasive orthogonal polarization spectral imaging as applied to microvascular studies in mice. Exp Diabesity Res 2004;5:211-7.
Lima A, Bakker J. Noninvasive monitoring of peripheral perfusion. Intensive Care Med 2005;31:1316-26.
Cerny V, Turek Z, Parizkova R. Orthogonal polarization spectral imaging. Physiol Res 2007;56:141-7.
Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJ, et al. Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability. J Appl Physiol 2008;104:845-52.
ADA. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006;29 Suppl 1:S43-8.
Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001;24:539-48.
Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 1999;100:1134-46.
Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 1975;35:609-16.
Nuchtere bloedafname (HbA1c)
Voedings- en activiteitendagboek 1 week voor aanvang Studie design Orthogonaal Polarisatie Spectrometrie
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