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The relation between vitamin D deficiency and depression in
Transcript of The relation between vitamin D deficiency and depression in
Aim of work
vitamin D levels in diabetics and control subjects.
vitamin D levels in type 1 diabetic patients with and without depression.
Subjects and Methods
A great proportion of patients with
type 1 diabetes were found to have low serum vitamin D
A great proportion of patients with
depression were found to have low serum vitamin D.
was a risk factor for developing vitamin D deficiency.
Diabetes mellitus (DM) is one of the most common non-communicable diseases (NCDs) globally. It is the
fourth or fifth leading cause of death
in most high-income countries and there is substantial evidence that it is epidemic in many economically developing and newly industrialized countries.
Diabetes is undoubtedly one of the most challenging health problems in the 21st century.
Diabetes mellitus is frequently associated with comorbid depression, contributing double burden to the individual and society.
prevalence of depression in diabetics is 2-3 times higher compared to non-diabetic.
Untreated depression in diabetes can increase the risk for diabetes-related complications – such as heart disease, blindness, amputations, stroke, kidney disease, and sexual dysfunction.
was in the world
in terms of highest number of people with diabetes in 2012 (more than
) and expected to be among ten countries with the highest number of estimated cases of diabetes for 2030.
© International Diabetes Federation, 2012
comparison between the different studied groups regarding their laboratory data
This study was conducted on
120 subjects aged 16-40
collected from outpatient clinic of Endocrinology and psychiatry & psychiatry unit of Ain shams University Hospital.
Comparison between diabetic and non-diabetic patients
Comparison between patients with depression and those without depression
Multiple regression model for determinants of vitamin D level
Vitamin D level in depressed patients according to their MADRS score
In recent years, studies suggesting that
vitamin D deficiency correlates with the severity and frequency of T1D
and that vitamin D supplementation reduces the risk of developing T1D have been reported.
The role of vitamin D in cognitive function and mental health has been reported.
concentrations have been shown to be
in patients suffering from
and have been associated with cognitive dysfunction.
30 type 1 diabetic subjects without depression
30 healthy control subjects (selected from healthy relatives of patients).
30 type 1 diabetic subjects with depression.
Screening for vitamin D
insufficiency is essential for all patients with diabetes and/or depression.
are needed about the association between vitamin D deficiency and depression in diabetic patients and the role of each one in the development of the other.
The role of vitamin D supplementation
in patients at risk of developing diabetes and/or depression is
a matter of debate
and we need more knowledge about that.
30 depressed subjects without diabetes.
Mean vitamin D level in the four study groups.
Error bars represent SD
Montgomery- Asberg Depression Rating Scale (MADRS)
was used to assess the presence of depression and 25 hydroxyvitamin D level by ELISA was used to assess vitamin D status.
Boxplot showing Vitamin D level in patients with or without depression. Central box represents interquartile range. Middle line represents median. Whiskers extend from minimum to maximum value, excluding outliers that are displayed as circles
Boxplot showing vitamin D level in patients with or without type I DM. Central box represents interquartile range. Middle line represents median. Whiskers extend from minimum to maximum value, excluding outliers that are displayed as circles