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Transcript of Microbiology Project
Jaclyn Morris Probiotics Probiotics: Microorganisms that beneficially
affect the G.I. tract of the host
-induce favorable microbial
balance in the gut How do probiotics work? What are they? What microbes are involved? Lactobacilli
L. casei, L. delbureckii subsp bulgaricus, L. lactis, L. rhamnosus (LGG), L. acidophilus, L. reuteri
S. cremoris, S. salivarius subsp thermophilus
B. bifidum, B. animalis (yogurt), B. infantis
Class 1 and Class 2 peptides Industrial Uses Cosmetic Uses Medical Application and Health Benefits Health Benefits (cont.) Collado, M., et. al. (2009) "The Impact of Probiotic on Gut Health." Current Drug Metabolism, 20, 68-78.
Fuller, R. (1991). Probiotics in human medicine. Gut: An International Journal of Gastroenterology and Hepatology, 32(4), 439-442.
Vaughan RB (July 1965). "The romantic rationalist: A study of Elie Metchnikoff". Medical History 9 (3): 201–15. doi:10.1017/S0025727300030702. PMC 1033501. PMID 14321564.
Fuller R (May 1989). "Probiotics in man and animals". The Journal of Applied Bacteriology 66 (5): 365–78. doi:10.1111/j.1365-2672.1989.tb05105.x. PMID 2666378
D'Arrigo, Terri. (2010). "American Gastroenterological Association." Probiotics: What They Are and What They Can Do For You. 15, 21-27.
Walker, Richard, and Merry Buckley. Probiotic Microbes: A Scientific Basis. Rep. American Academy of Microbiology, 6 June 2006. Web. 18 Apr. 2013. <http://www.isapp.net/docs/AAM_probiotic_report_june_06.pdf>.
Kim, E., Hong, K., Choi, K., Han, Y., Kangwan, N., Cho, Y., Hahm, K., & , (n.d.). High concentrated probiotics imporve infammatory bowel disease better than commerical concentration of probiotics. (2012). Journal of food and drug analysis, 20, 292-295.
Hickeson, M. (n.d.). Examining the evidence for the use of probiotics in clincial practice. (2012). Nursing Standard, 27(29), 35-41.
Kumar, M., Nagpa, R., Verma, V., Kimar, A., Kaur, N., Hemalatha, R., Gautam, S., & Singh, B. (n.d.). Probioc metabolics as peigentics targets in the preventio of colon cancer. (2012). Nutrition Reviews, 71(1), 23-34. doi: 10.1111/j.1753-4887.2012.00542.x
Johnston, B., Ma, S., Goldenberg, J., Thorlund, K., Vandvik, P., Loeb, M., & Guyatt, G. (n.d.). Probiotics for the prevention of clostridium difficile-associated diarrhea: a systematic review and meta-analysis. (2012). Annals of internal medicine,157, 878-888.
Cordina, C., Shaikh, I., Shrestha, S., & Camilleri-Brennan, J. (n.d.). Probiotics in the management of gastrointestinal disease: analysis of the attidtudes and prescibing practices of gastroenerologists and surgeions. (2011). Journal of Digestive Diseases,12, 489-496. doi: 10.1111/j.1751-2980.2011.00534.x
Ritchie, M., & Romanuk, T. (n.d.). A meta-analysis of probiotic efficacy for gastrointestinal diseases. (2012). Plos One, 7(4), doi: 10.1371/journal.pone.0034938 Works Cited Health Benefits: Gut Health
Helicobacter pylori infection
Clostridium difficile-associated diarrhea
Pouchitis 1. Treatment of diarrhea 2. Treatment of Inflammatory bowel disease History Early 1900's
The idea of the probiotic was first introduced by Élie Metchnikoff
Proteolytic enzymes in the gut caused aging
Replace harmful microbes with beneficial microbes
Lactic acid bacteria with fermented milk lowers the pH of the gut destroying harmful proteolytic enzymes
Cultures that consumed larger quantities of milk lived longer
Lactobacillus acidophilus uses with constipation
Term 'probiotic' coined by Werner Kollath Good: Bifodobacterium
Protect excess weight gain Bad: Clostridium and Staphylococcus
L. rhamnosus to pregnant women and newborns
Not cure all! (pollen) Good: Bifidobacteria and Enterococcus Allergies Obesity Nutraceutrical and Cosmeceutical products ---aimed at enhancing consumer well being and appearance Product: Bonicel-improves skin hydration, elasticity, under eye puffiness and reduces fine lines and wrinkles in humans Clinical trials with probiotic technology Other Potential Uses Maintaining a healthy mouth, preventing and treating certain skin conditions like eczema, promoting health in the urinary tract and vagina, and preventing allergies. Yeast infections Colon Cancer Use on Animals Animal feeds
Help with: growth efficiency, immune health, and improved milk yield and quality. Mechanisms 1. Production of Antimicrobial Substances reduce the number of viable cells
affect the metabolism or toxin production of the intestinal bacteria 2. Competition for Adhesion Receptors adhere to the epithelial wall and compete with pathogens for the adhesion receptors 3. Competition for Nutrients In vitro results suggest that gut micro-organisms compete more efficiently than C difficile for monomeric glucose, N-acetyl-glucosamine, and sialic acid. 4. Stimulation of Immunity Lactobacilli administeredby mouth can stimulate macrophage activity against several difference species of bacteria BIOL 304- Microbiology
Dr. C. Sempertegui