Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

The role of biomechanical modelling in discovering the brain's lymphatic system

No description
by

Alexandra Diem

on 30 September 2017

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of The role of biomechanical modelling in discovering the brain's lymphatic system

Alexandra K. Diem
EPSRC Doctoral Prize Research Fellow
University of Southampton

http://www.akdiem.com @akdiem A.K.Diem@soton.ac.uk
Injection experiments in mice reveal tracer pathways
Carare et al. (2008), Neuropathology and Applied Neurobiology 34 (2): 131-144
The role of biomechanical modelling in discovering the brain’s lymphatic system
Tracer pathways correlate with Alzheimer's pathology
Cerebral artery anatomy 101
Basement membrane: Thin film flow inside a porous medium
IPAD through the MCA
Keable et al. (2015), Biochimica et Biophysica Acta 1862 (5): 1037-1046
Diem et al. (2017), Frontiers in Neuroscience 11:475
Boundary conditions:
Blood flow through the MCA
Olufsen et al. (2000), Annals of Biomedical Engineering 28 (11): 1281-1299
https://github.com/akdiem/vampy
Diem and Bressloff (2017), Journal of Open Research Software 5:17
q = -1.12e-3 um3/s
for
K0/K1 = 0.01
A single turnover of ISF (280 ml) would take 1e11 days (0.3 billion years)
IPAD is pretty weak!
What's going on?
Neurovascular unit to the rescue!
Diem (2017), ReScience 3(1): 9
Witthoft and Karniadakis (2012), Journal of Theoretical Biology 311: 80-93
Neurovascular unit to the rescue!
Thanks!
Neil
Bressloff
Roxana
Carare
Giles
Richardson
http://akdiem.com
https://www.cararegroup.org/
Experimental verification
Diem et al. (2017), Frontiers in Neuroscience 11:475
Diem et al. (2017), Frontiers in Neuroscience 11:475
Matthew
Sharp
Maureen
Gatherer
NVU model is quite robust
BM pressure is directly proportional to artery wall stress
Diem et al. (2017), Frontiers in Neuroscience 11:475
Boundary conditions:
Airy stress function:
Full transcript