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U937 Cell Line background

Monocytes, Macrophages, and Dendritic Cells, Oh MY!

Amanda Groziak

on 19 July 2013

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Transcript of U937 Cell Line background

About the U937 Cell line:
37-year-old male patient with histiocytic lymphoma
Myeloid lineage cells (monocytes and macrophages)
Basics of Monocytes
Myeloid cell lineage
Innate Immunity / first responders
Can differentiate into macrophages or dendritic cells
binds its pathogen recognition receptors (PRR) to pathogen-associated molecular patterns (PAMPs) on viruses/bacteria
phagocytosis of pathogens and
relay signal to other immune system cells
Basics of Macrophages
Basics of Dendritic Cells
Antigen-presenting cells
present in tissues in contact with external environment (e.g. skin, inner lining of nose, lungs, stomach, intestines
undifferentiated state in the blood
produce IL-12 which stimulates helper T-cell maturation
produce INF type 1 which bind to INFa receptors and recruit macrophages
Works Cited:
NCBI database
Basic Pathology 3rd Edition
USMLE Animated Immunology
youtube video
phagocytes (endocytosis)
activated by cytokines, travel through the blood stream to infection site
present in liver, spleen, bone marrow, lymph nodes, nervous system (microglial cells)
engulf pathogens and display antigens on surface (MHC complex)
By: Amanda Groziak
Full transcript