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DOPAMINE

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by

Julia Borella

on 14 March 2015

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Transcript of DOPAMINE

Introduction
4-(2-Aminoethyl)benzene-1,2-diol
History
Occurrence in Nature
Humans and other animals
DOPAMINE
Catechol
Amine
C8H11NO2
chemical messenger
hormone
neurotransmitter
Monoamine
8 x
C
= 8 x 12.01 = 96.08
11 x
H
= 11 x 1.01 = 11.11
2 x
O
= 2 x 15.99 = 31.98
1 x
N
= 1 x 14. 00 = 14.00
Total =
153.18
grams per mole.
Molar Mass
218-220 °C
None...
337 °C
gray-white fine powder
Chemical properties and reactivity
Soluble in:
water
methanol
hot 95% ethanol
Highly sensitive to:
oxygen
light
Extremely unstable in alkaline media.
C= 62.7 %

H=7.23 %

O=20.9 %

N=9.14 %
Odorless
Bitter-tasting
Hazards & Safety
Possibly cause irritation:
Eyes
Skin
Respiratory tract
For protection, wear:
Goggles
Gloves
Appropriate clothing
When heated to decomposition, releases toxic fumes of nitrous oxides
1910
George Barger
and
James Ewens
London, England
1958
Arvid Carlsson
and
Nils-Åke Hillarp
Sweden
2000
Arvid Carlsson
Nobel Prize
demethylation using hydrogen bromide
phenylalanine
and
tyrosine
Production
Reactions occur in the brain and other parts of nervous system
Also a chemical messenger in other parts of the body (eg. reduces insulin production)
(Ventral Tegmental Area)
schizophrenia
ADHD
OCD
increases when you get chocolate
Parkinson's
tremor
akinesia
rigidity
Schizophrenia
medicines block reactors
ADHD
medicines increase levels
Parkinsons'
L-DOPA
Dopamine cannot cross the blood-brain barrier
Does not directly affect CNS
Increased heart rate and blood pressure
Usage
In Popular Culture
"dope"
= heroin
posters
T-shirts
jewelry
tattoos
Bibliography:
Websites:
http://www.chem.ucla.edu/harding/MoleCools/MoleCools_D/MoleCools_D.html (24.2.15)
https://www.psychologytoday.com/basics/dopamine (24.2.15)
https://prezi.com/w35zuw_kmoem/edit/#65_45341393 (24.2.15)
http://www.theguardian.com/science/2013/feb/03/dopamine-the-unsexy-truth (24.2.15)
http://dopamineproject.weebly.com/properties.html (24.2.15)
http://www.physicsclassroom.com/class/light/Lesson-1/Polarization (26.2.15)
http://pubchem.ncbi.nlm.nih.gov/compound/dopamine (26.2.15)
http://www.encyclopedia.com/topic/dopamine.aspx (26.2.15)
http://www.chemspider.com/Chemical-Structure.661.html (26.2.15)
http://flexikon.doccheck.com/en/Dopamine (4.3.15)
http://learning.blogs.nytimes.com/2009/10/28/the-straight-dope-the-role-of-dopamine-in-the-brain/?_r=0 (4.3.15)
http://www.nytimes.com/1996/03/19/science/how-brain-may-weigh-the-world-with-simple-dopamine-system.html (4.3.15)
http://www.lookchem.com/Dopamine/ (4.3.15)
http://scicurious.scientopia.org/2010/08/26/back-to-basics-4-dopamine/ (4.3.15)
http://nihseniorhealth.gov/parkinsonsdisease/whatcausesparkinsonsdisease/01.html (5.3.15)
http://psychcentral.com/lib/the-dopamine-connection-between-schizophrenia-and-creativity/0003505 (5.3.15)

Pictures:
http://i.kinja-img.com/gawker-media/image/upload/s--N7cZEi7n--/c_fit,fl_progressive,q_80,w_320/18dy716cftokqjpg.jpg (24.2.15)
http://thumbnails-visually.netdna-ssl.com/slacker-or-gogetter-the-dopamine-connection_50291a89308b9_w1500.jpg (24.2.15)
http://fc01.deviantart.net/fs70/f/2013/290/8/f/dopamine_iphone_wallpaper_by_derdan93-d6qs1jw.jpg (24.2.15)
http://proteopedia.org/wiki/images/2/28/Dopamine_levels.jpeg (4.3.15)
Full transcript