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Diffusion MRI

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by

Matthan Caan

on 21 September 2016

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Transcript of Diffusion MRI

acquisition
white matter
diffusion
2D
3D
signal
tensor
one voxel
eigenvalues: shape/size
eigenvectors: orientation
estimation
decomposition
shape factors
radial diffusivity
axial diffusivity
mean diffusivity
diffusivity
FA
0<FA<1
fractional anisotropy
colored by orientation
gradient directions distributed on a sphere
DWIs
no diffusion
weighting
diffusion mri
matthan caan
processing
noise filtering
adaptive lmmse-filter
motion / eddy current distortion correction
outlier detection
S(g)
D
diffusion weighted image (DWI)
b-value: length/strength of diffusion-weighting
analysis
voxel-based
tractography
corticospinal tract
1. manual fiber tracking in each subject
2. warp fibers with FA to ICBM-FA template
3. sample FA-profile along tract
non-rigid tensor-based registration towards population-averaged template
voxel-based analysis on FA
more
pathology and diffusion
post-processing
tractography methods
tensor-based registration
multimodal analysis (fMRI,sMRI)
crossing fibers
...
m.w.a.caan@amc.nl
tensor estimation
orange.ebioscience.amc.nl/ebioinfragateway/
non-rigid tensor registration
population-averaged atlas
DTI atlas
FSL BedpostX
probabilistic tractography
DTI preprocess
Least Squares
fiber tracking
FA: brightness
orientation: color
*
streamline
eigenvector field
seed/OR ROI
waypoint/AND ROI
Ensure that tracks are anatomically valid!
High chance of false positive findings.
cingulum
uncinate fasciculus
AD
RD
Full transcript