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Copy of FREE TEMPLATE - Perfect Curriculum Vitae
Transcript of Copy of FREE TEMPLATE - Perfect Curriculum Vitae
Non- Pharmcoogical treatment
Irritable Bowel Syndrome
Prof . Dr . Osama Ibrahim
The Main Symptoms of IBS
1) Altered somato-visceral and motor dysfunction of intestine
2) post infectious IBS
Rham Elsaid Atya Abo Hmza
Rham Abd El Star Mohamed Edres
Rawda Mohamed Mohamed Mahfouz
Rwyda Mostfa Mostfa Eldory
Rwyda Hesham Sad Mohamed Omr
Reem Ibrahem Ahmed Abo Sliman
Reem Reda Ibrahem Ahmed yones
Reham Ibrahem Ahmed Fouda
Reham Ibrahem Abd Allh Ibrahem
Reham Ibrahem Mohamed El Awadا
Factors of IBS
4)Hormonal change play role in trigger IBS in women
1) Blood tests as CBC and ESR
2) Stool Tests
3) Barium enema
6) Computerized tomography (CT) scan
7) Investigating 'red flags'
1-BRAN (dietary fiber)
3- Tegaserod (zelnorm)
Pain in IBS
2-Antidepressant medication (TCA+SSRI)
Newly approved drugs of IBS
Many people who have IBS seem to have unusually sensitive intestines. .
Irritable bowel syndrome is a gastrointestinal disorder .
2) Regular exercise, yoga, massage or meditation
1) Life style modification
*Changes in bowel movement (diarrhea or constipation)
* Bloating and excess gas.
* Mucus in stools.
* Abdominal pain .
* Anxiety or depression.
* An unpleasant taste in the mouth.
* Urinary symptoms.
3) post inflammatory IBS
Main syptoms of IBS abdominal pain, cramping or bloating, and diarrhea or constipation.
Group (c) : 421- 430
Gastric compliance in the fasting period and in the postmeal period after administration of the intraduodenal lipid infusion
Tegaserod significantly increased postmeal gastric compliance in patients with (FD), *P = 0.04 vs. placebo. (HVS) showed increased gastric compliance in the postmeal period after pre-treatment with placebo, **P = 0.03 vs. tegaserod, FD.
During the 30-min period after starting the intraduodenal lipid infusion, median bag volumes in healthy volunteers were higher for tegaserod 6 mg b.d. when compared to placebo (P < 0.05)
Gastrointestinal syndrome .
Abdominal pain , bloating , diarrhea and or constipation) .
IBS C , D and A زز
No specific test to diagnose IBS .
Effect of tegaserod on gastric compliance
Effect of tegaserod on gastrictone and accommodation
Tegaserod enhances postprandial gastric compliance in functional dyspepsia patients and gastric accommodation in healthy volunteers.
Approved May 2015
Factors of IBS
Symptoms of IBS
Non- pharmacological treatment
Newly approved drugs
Herbsو, Hypnosis , Probiotics and life style modifications .
BRAN , Psyllium and Tegaserod .
loperamide , Alosteron and Cholestyramin ز.
Rifaximin , Eluxadoline and GATTEX .
Clinical trial: effects of tegaserod on gastric motor and sensory function in patients with functional dyspepsia
Effects of tegaserod on gastric compliance, accommodation and gastric sensory function
The Novartis Drug Supply Management Group
Double-blind, Randomized, Crossover design
Tegaserod postprandial gastric compliance in (FD) patients (P=0.04).
post prandial gastric compinace placebo in hvs (p=0.03)
Analysis of gastric accomdation signficant ↑in intrabag volume with tegaserode in hvs (p= 0.04)