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StatGenet@Kyoto for McGill

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by

Ryo Yamada

on 13 April 2018

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Transcript of StatGenet@Kyoto for McGill

https://www.facebook.com/statgenetKyoto
https://www.genome.gov/26525384/
2005
2013
2003
2001
2003
Started from Here
Members
What we are doing
Shape & Movement of Cells
Flow Cytometry Data Analysis
Discrete Data Analysis
Decision Theory
Information Geometry
Simply speaking...
Diseased
Healthy
MM Mm mm
No. SNPs
http://www.opir.kyoto-u.ac.jp/study/en/why/
Diseased
Healthy
MM Mm mm
No. SNPs
Phenotypes
Quantitative biology
Time, Space
Omics
{0, 1}
Phenotypes
more
complicated

Discrete Exterior Calculus
Probability Distribution
Non-parametric
Information Geometry
https://www.slideshare.net/tamurashinichi/20140611-prml-slidesrev
https://academic.oup.com/bib/article-abstract/doi/10.1093/bib/bbx012/3038466/Strategies-for-processing-and-quality-control-of?redirectedFrom=fulltext
http://physiology-physics.blogspot.jp/2010/09/fmri-bold-and-beautiful.html
Diseased
Healthy
MM Mm mm
No. SNPs
Integer x Integer Table
Generalization
Int x Int x ... x Int
Independency test (χ-squared)
Asymptotic assumption
Phenotye{0,1} x SNP1 x SNP2 x ...
Geometry
DOI: 10.1109/ISIT.2016.7541364
2^n multi-array's structure
Information geometric decomposition

Simply speaking...
Diseased
Healthy
MM Mm mm
No. SNPs
Personalized medicine
Decision should be
Based on study results
That are stochastic
With uncertainty
Information
Action
Decision-maker
Deterministic
Only-one
Decisio-maker
stacks into the problem called
"multi-armed bandit problem".
Heterogeneous decision makers
can avoid
"multiarmed bandit problem".
When people take turns to make a decision and people's attitude are heterogeneous, it is good.
Non-deterministic
Only-one
Decision-maker
can avoid
"multiarmed bandit problem".
When a person make heterogeneous decisions upon the same information input, it would be good.
Brain could be quantum computer
to make heterogeneous stochastic decisions...
Serial decision process is a Memory-Positive Discrete Stochastic Process
States are in discrete data structure
Stochastic process
Brownian motion on state space
Brownian map
How to fight against quantitative biology in Kyoto
https://trulytokyo.com/tokyo-or-kyoto-which-should-you-visit/
Sphere
Graph structure
Stochastic process
Spherization of table-space
Geometry
Sphere
Graph
Stochastic process
Discrete Exterior Calculus
Probability Distribution
Non-parametric
Graph structure
Stochastic process
Brownian motion on state space
Brownian map
Stochastic process
Spherization of table-space
Center for Genomic Medicine
Kyoto Univ.

Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study)
a longitudinal prospective study of 120,000 individuals from a single city in Japan.
http://www.mcgillgenomecentre.org/kyoto-mcgill-super-university-project
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Four Strategies
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