Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

PharmacoGENOMICS

No description
by

Vatsal Thakkar, M.D.

on 5 March 2018

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of PharmacoGENOMICS

PharmacoGENOMICS:
Moving Psychiatry into the 21st Century

by Vatsal G. Thakkar, M.D.
NYU School of Medicine

view this on www.prezi.com
Genes + Environment = Phenotype (the patient)
SSRIs
Non-SSRIs
Benzodiazepines
Stimulants
Mood Stabilizers
Antipsychotics
27 + 7 + 11 + 22 + 8 + (27) =
75 psychotropics
Non-Stimulants
Genomics in Medicine
Conflicts of Interest:

1. NONE.
Why is data useful?
$
vs.
Salient Genes for
Psychiatry:

MTHFR: the Folic Acid Gene
COMT: the Dopamine Enzyme
Are you a WORRIER or a WARRIOR?
COMT: Val-Val | Val-Met | Met-Met
Gene Testing companies
(Neuroscience)
SLC6A4:
the Serotonin Transporter
a mutation indicates higher risk of stress disorders AND lower response to SSRI medication
Other Genes
CYP450: Liver Metabolism
BDNF
GRIK1
OPRM1
ADRA2A
5HT2C
MC4R
Ion Channels: Ca+ and Na+
All mood stabilizers work to stabilize these ion channels: lithium, antipsychotics & anticonvulsants
as well as OMEGA-3 Fatty Acids
types of tests: brain chemistry & drug metabolism
(genes: CACNA1C & ANK3)
Full transcript