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Longevity Aegon 2016 04

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Raymond McCauley

on 10 October 2017

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Transcript of Longevity Aegon 2016 04

+1-650-776-4561
for your attention
Raymond McCauley
biochemistry
biophysics
electrical engineering
computer science
bioinformatics
nanotechnology
genetic engineering
DNA sequencing
personalized health
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
systems
biology
past:
Biotech Chair: Singularity U
Co-Founder: Playtpus Project
Co-Founder & Chief Architect: BioCurious
Principal: Exponential Biosciences

Current Research Areas:
Personal Genomics
Therapeutic Genetic Engineering
Low Cost Access to Biotech Tools
Cancer Dx and Treatment
Singularity
University
Raymond McCauley
@raymondmccauley
Thank you
Raymond McCauley
The Business of Longevity
raymond@singularityu.org
+1-650-776-4561
http://rockhealth.com/tag/wearables/
One More Thing...
from being in
an exponential business
Find an exponential trend,
then hitchhike
A prototype beats a plan
Product Development Process (PDP)
typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk
Nothing fades faster than last year's technology
2008
$500K
2012
$1
People
Teams
Interdisciplinary
Disruption
is never
Expected
Salim Ismail
Add a specialty
Be half of a team
Assemble a varied team
Find translators
Develop internal people
Innovation Lessons
Triple Major?
Design Your Own Major?
Makes vaccines using mRNA from diseases
"Vaccinated with information"
Gates Foundation invests $57M
"Cellular scissors chop up HIV virus"
Salk Institute
Nature Communications "Use of the CRISPR/​Cas9 system as an intracellular defense against HIV-1 infection in human cells", Liao et al
23andMe and Apple
enter drug research business
"crowd-sourced clinical trials"
Apple ResearchKit
- Asthma
- Parkinson's Disease
- Breast Cancer
- Diabetes
- Cardiovascular
Enrolled 7400+ people in 24 hours.
Previous largest study was 1700.
Live Longer or Die Trying
advisor,
consultant,
investor
People who never got:
cancer
cardiovascular disease
neurological conditions
Q: Secret to live a long time?
A: Pick good parents!
Implants are Easy and Coming Soon
Biosensing
and
Command & Control
Biosensing implants in development
blood sugar
blood chemistry
temperature, blood pressure, ECG
heart attack, stroke early warning
Longevity
Squaring the
Survival Curve
Limit at 120, for a while
Overpopulation? No
Proposal: Longevity Lab
Cell
Repair
Technologies
Accidental death
by 190
on average
Pensions & Advanced Health Accounts
It Varies, by Disease & Country
Hans Rosling's
Gapminder
Life Expectancy +29.2 years

Deaths in ages 0-5
1900: 30.4%
2000: 1.9%
Sanitation
Water
Access to
Antibiotics
Death Be Not Proud, Part 1
What We
Die From
Beyond 120?
Death is not a Democrat
I intend to live forever. So far, so good. ~Steven Wright
Life Expectancy +25

Deaths in ages 85-110
2000: ~50%
2030: ~10%
Death Be Not Proud, Part 2
Genome Project Dividend
Worldwide Infectious Disease
Extend Healthspan
cancer
cardiovascular disease
neurological conditions
Autoimmune, Affluence
Health Surveillance
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Genetic engineering
Stem cell therapy
Melanoma repair
DNA cross-checking
DNA repair
DNA
Cryonic recovery
Cell reprogramming
Death Be Not Proud, Part 3
Cryonics for
Organ Replacement
Organ Preservation Alliance
DNA
Nanobots
Stem
Cell Tx
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behavior Change
Underestimate Savings Need
Health Care Cost Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
Longevity Escape Velocity
+ 3.0 months / year
+ 2.5 months / year
120
0
5
80
Age
% Pop
Longevity Curve
120
0
5
80
Age
% Pop
Longevity Curve
Quantified Self
Biosensors
Notes:
Add Survival Curves, years to different death thing
Add references to money pieces (& add money figures)
SHow how actuarial curves are always wrong
Call new tech "deal breakers" "disruptions"
Discuss Longevity Escape Velocity as a Moore's law -- driven by economics
Ray Kurzweil prediction: +1 year / year by 2029
- 19 April 2016, "Reinvent Yourself: The Playboy Interview with Ray Kurzweil"
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