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Schistosoma

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maryam abdelghani

on 20 February 2013

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Transcript of Schistosoma

Pathobiology 1-3-2013 Maryam Abdelghani, M.D SmPEPCK liver - granuloma rectum 20 weeks

- spleen: body
- immunological
- histological MODERATE
SPLENOMEGALY HYPERSPLENOMEGALY extract proteins TRANSFERRIN - negative acute phase reactant
- 2.5 to 4.6 fold increase in HSS (not MSS)
- schistosomes require iron and bind host transferrin
for development Major urinary protein - lipocalin protein in mice
- similar to "human epididymis-specific lipocalin 9"
- 5 spots with 2-10 fold decrease in HSS
- 2 spots 2.6 fold decrease in MSS - S. mansoni phosphoenolpyruvate carboxykinase
- antigen for shistosome infection
- increased > 13 fold in HSS
- increased 8 fold in MSS - structural
- immune response
- acute phase - energy metabolism
- choline metabolism
- xenobiotic metabolism Critique n= 5 for each group
repeated test with similar results

can't be utilized as test yet, no cut-off

animal model, different proteins in humans?
need more studies conclusion transferrin, MUP, SmPEPCK among others, can be potential diagnostic biomarkers in early detection and treatment of schistosomiasis patients

Transferrin isoforms and MUP isoforms were significantly altered in HSS mice

Liver protein abundances differ between MSS and HSS mice, can be used as diagnostic markers for early detection of hepatosplenic schistosomiasis Thank you Dr Guarner
Dr Hill
Dr Mass-Moya References - Mandell, Douglas and Bennett's Principles and practice of infectious diseases, fourth edition
- Diagnostic pathology of infectious disease, Richard L. Kradin
- Michelle L. Steinauer, The sex lives of parasites: Investigating the mating system and mechanisms of sexual selection of the human pathogen Schistosoma mansoni, Int J Parasitol. 2009 August; 39(10): 1157–1163.
- Wilson RA, The saga of schistosome migration and attrition.Parasitology. 2009 Oct;136(12):1581-92. doi: 10.1017/S0031182009005708. Epub 2009 Mar 5. differential
patterns
of protein
expression
Full transcript