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DRUGS

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by

GERALDINE MERAT

on 10 November 2015

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Transcript of DRUGS

Drug issues
the perfect whatever drug
recreational drug
provoke euphoria

Ingredient:
fat,sugar,tryptophan,phenylethylamine
Food wich brings energy
:
instinct
ADDICTION
GENES AND ADDICTION
SOME OF THE GENES INVOLVED
The A1 allele of the dopamine receptor gene DRD2
people addicted to alcohol or cocaine
protective allele of the CYP2A6 gene
two copies of the ALDH*2 gene variation
non-smokers more likely than smokers
nausea and dizzizness
rare cases of alcoholism
ADDICTION
I. What is an addiction
II. How does it work
III. Exemple of addictions
IV. How to treat addiction
b. Cannabis
a. Heroin
d. Chocolate
c. Sport
a. Mecanism
b. Predisposition
a. Little history
b. Definition
a. Therapy
b. Rehab
What is an addiction ?
Medical
Way of administration
MARIJUANA
Cannabis plants produce Cannabinoids
Mild withdrawal syndrome
irritability
mood and sleep difficulties
sleep disturbances
decreased appetite
restlessness
cravings
boredom
anxiety
Inhibitory neuron
Dopamine-releasing VTA neuron
Cerebral neuron of reward pathway
Opium and heroin decrease ativity of inhibitory neuron
Nicotine stimulates dopamine-releasing VTA neuron
Cocaine and amphetamines block removal of dopammine from synaptic cleft
Predisposition:
biological differences
vulnerable to addiction
Genetic research:
Identified "drug target"
Medication based on individual's genetic profile
you are prone to adictin doesn’t mean you’re going to become addicted . It just means you’ve got to be carefull
Chocoholics
powerfull urge to eat : addiction?
instant feelling of well being
Most frequently craved food
Habit-forming
diamorphine/opioids

powerful analgesic

Morphine

Use in UK
HISTORY
Old World
New World
Opium Cannabis Alcohol
Drug issues
Tobacco Cocaine
Shaman
Medical use
Greek
Natives
the perfect whatever drug




recreational drug


p
r
o
v
o
k
e

e
u
p
h
o
r
i
a
In Antiquity they already described the problems of those substances
Chocolate
Chocolate
Tryptophan (amino acid) :
precursor to serotonin,
involved in regulating moods
high serotonin levels can produce feelings of elation.

Phenylethylamine (from which amphetamine is derived) :
"chocolate amphetamine" and can cause feelings of excitement and attraction.
food which brings energy:
instinct
Ingretient
:Fat,Sugar,Tryptophan,Phenylethylamine
Injection


inhalation



Oral
have to undergo detox treatment.
Withdrawal symptoms
Cold shakes
Bone pain
Chills and sweating
Fever-like symptoms
Insomnia
Mood swings
Diarrhea
Anxiety and depression
Vomiting
WITHDRAWAL SYMPTOMS
"Addiction is defined as not having control over doing, taking or using something to the point where it could be harmful to you"
Withdrawal symptoms
SPORT
Half of the High-level athlete
are addicted to sport
Endorphines issues
No effective pharmacotherapy
Research

Vaccins
All isn't kwnon about addiction's mecanisms
ADDICTION
HEROIN
Sign and Symptoms
Continues despite health problem
Social and/or recreational sacrifices

refuse to admitt
Secrecy and solitude
Taking risks
Denial
XVIII th
Dropping hobbies and activities
(
Relationship problems
)
Public health issue
Chinese addict to opium
Benjamin Rush
"Father of American Psychiatry"
to Maintaining a supply
Old World
New World
Medical use
Sign and Symptoms
Today most of those substance are illegal
Substances
CULTUR SM
BEFORE
AFTER
Gamma-hydroxybutiric acid (or GHB)
TRE
AT
MEN
TS
TREATMENTS
Feeling of power
Regain normal life
Safe and healthy way
Compulsive need
withdrawal symptoms
Sport: a "narcotic" As a remedy to body or mental suffering
Muscle tiredness
Anabolic steroid
Beta-Hydroxy beta-methylbutyric
acid (or HMB)
Substances
MECANISM
MECANISM
Reward System
discovered by James Olds and Peter Milner
in 1956
Specie survival
Reward System
discovered by James Olds and Peter Milner
in 1956
Specie survival
New mecanism
Serotonin
Endorphins
New mecanism
Serotonin
Endorphins
New mecanism
Serotonin
Endorphins
Dependence : low level of dopamine
Dependence : low level of dopamine
Full transcript