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Transcript of Tuberculosis
Mycobacterium Tuberculosis (Mtb)
1/3 of world's population
Claims 1.6 million / year
People with HIV...
How is Tuberculosis spread?
How do you feel when infected?
Active TB sneezing
Millions of contaminated droplets
When inhaled, person is at risk of catching TB
Settles in lungs (macrophage)
Why is Tuberculosis still a major killer?
Proper diagnostic tools...
But because of DR Tb & MDR Tb...
Why does Mtb survive in people with healthy immune systems?
How Does Mtb become "Latent"?
-Mtb Latent to FICS
Final Immune Containment Strategy
-Seattle BioMed & Central
Diagnostics, drugs, and vaccines
Finding cures & decreasing active TB
Uncovering specific genes
Conditions of Mtb
Clarifying Any Questions
What is Tuberculosis?
Very ancient disease
19th century devastation
Mycobacterium tuberculosis (Mtb)
2nd most common cause of death
3 Major Types
Mtb spreads all over the lungs
Loss of appetite
Disease may be dormant for decades...
Immune system maintains it...
When the immune system becomes weak...
The dormant TB bacteria reactivates
Fatigue and weight loss may follow
Diagnostic Tools Used
PPD (Purified Protein Derivative Test)
RFLP (Restriction Fragment Length Polyphorism)
Length of Tb Treatment
When people stop taking their medication...
Vaccine vs. Latent Tb
The current Tb vaccine is not effective towards latent Tb
Cost to Treat Tb
Vaccine vs. Active Tb
BCG (bacillus Calmette–Guérin)
Places Most Affected
-TB is 2nd killer disease
-2011: 8.7 million had TB
-1.4 million died of TB
-95% of TB in lower-middle income countries
-3rd cause for women death
-By 2015 TB rates decrease
TB Occurs Worldwide
-Asia 2011: new cases
-60% new global cases of TB
-Sub-Sahara Africa has most new cases
-260 cases per 100,000 population
-2011: 80% TB in 22 countries
-Brazil & China are slowly declining
-Cambodia fell 45% in last decade
An infectious disease that may affect almost any tissue of the body, Especially the lungs, caused by the organism Mycobacterium Tuberculosis, and characterized by Tubercles.
Tb in Society
8.7 million infected
1.4 million died
Most Tb can be cured
U.S. Tb cases have decreased
50%< foreign people
Half of the cases:
"Great White Plague"
Poor sanitary conditions...
Over 9,000 years old
1.4 million deaths annually
Can be fatal...
-Other body parts
Most commonly affects:
-Liver or kidneys
When Left Untreated...
Just a little more information...
One sneeze = 150 people
Most commonly used:
Rifampin (Rifadin, Rimactane)
Side Effects of the Drugs
Loss of appetite
By: Dayssy Solis,
and Sophia Rodriguez
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The current Tb vaccine is not effective towards active Tb
After 4-10 weeks with no treatment...
Primary Pulmonary TB
Directly Observed Therapy Short-course
Day 4 & 5
Part A: Data Analysis
Part B: Gene Expression Analysis
Part C: Data Analysis
Day 5: Presentation
The search for a vaccine...
To begin with...
Question: In what circumstances does Tuberculosis survive in?
Lexi: I predict that Tuberculosis will thrive in the hotter temperatures because the disease is mostly found in warmer areas of the world, such as Africa.
Dayssy: I believe Tuberculosis will survive better in the warmer temperatures because bacteria grows better in warm temperatures than cold temperatures.
Sophia: I believe that Tuberculosis will survive better in warmer, more humid conditions because bacteria prefers warmer weather.
Setting up cultures:
Set up bacteria under different circumstances
Isolating Messenger RNA
Finish RNA Purification:
Used Isopropanol and Ethanol
Broke down DNA
DNASE Treatment to Degrade any DNA Present
QIAGEN RNEASY Purification
Day 4 & 5
All in all...
Inconclusive due to uncontrollable circumstances