Calculus Applicability in Science - Many science students (other than engineering or physics majors) wonder why calculus is a

requirement

- Proposing this class

- Prerequisites: Calculus 1, General Chemistry, General Biology

- Hands on and newer technology, critical thinking - Understand applications of calculus in the science fields

- Learn how to convert models into differential equations

- Develop critical thinking skills and learn to use new technology

- Explore careers and career outlooks Goals and Objectives Example:

If a patient at time 0 has a concentration of 25 micrograms/mL of a drug in their blood. At time 24 hours the concentration is 5 micrograms/mL, what is the concentration of the drug between these times?

How to solve these kinds of problems:

To solve this, we have to follow first order kinetics (an order of a chemical rxn that depends on the concentration of only one reactant and is proportional to it) Pharmacokinetics - Conversion of rate equation for "x" into an equation of "x" versus time (integrated equation)

- Integration = "sums the information from small time intervals and gives a total result over a larger time period" ex: used for drug efficiency/dosage forms by taking the area of the plasma concentration vs. time graph Pharmacokinetics Pharmacokinetics - Study of kinetics of administered drugs and the rate of their absorption and elimination

- How is calculus involved?

- Differential Calculus is used to study the

rates of processes

- Calculus comes in when we look at

small time intervals Pharmacokinetics This equation describes the rate of elimination where k= rate constant, x= amt of drug remaining -Differentiation = "breaking a process down to look at the instantaneous process" Pharmacokinetics - Many pharmacy, veterinary, or medical students learn the mathematical concept of geometric series in calculus II.

- Geometric series = the ratio of each term to the one after it is a constant, r (in this case).

- Another definition is a half life when half of the drug concentration will have declined. Initial concentration is mesaured immediately after injection and r is the fraction of the drug eliminated per unit time. We will be looking at half-lives with geometric series. C1 represents the concentration after the first half-life. Derivation of Drug Elimination Formula - Amount of drug remaining after 2nd half-life - Amount of drug remaining after "n" half-lives - Multiply both sides by "r" - "r"= 1/2 and 2Cinir=Cini and adding Cini to right side - Substitute this equation into the equation above - By substituting in r=0.5 - "b" is the fraction of the drug eliminated per unit time. - Any positive base

can be written as a

power of "e". "r" is the fractional

rate of drug removal Drug Accumulation Formula - The formula for drug accumulation is also a derivation process starting off with a geometric series: As "n" approaches infinity, the drug level levels off and can't get past a certain concentration Accumulation and Elimination Standard curve for determining dosage intakes and dosage control. You need 5 half-lives to eliminate a particular drug Trapezoidal Rule - In toxicology (study of the adverse effects of chemicals), AUC (area under the curve) can be used as a measure of drug exposure

- In Pharmacokinetics, AUC can be used to determine other parameters such as bio availability or clearance Trapezoidal Rule - One way to calculate the area under the curve is through the trapezoidal rule (similar to Riemann sums) Euler's Method - Point slope method and can be used to integrate

- Initial amount or concentration of the drug is the point, and the differential equation is the slope <= Get slope from this equation

* Use this slope for a finite step size and use it as a starting point to calculate another step size Sample Problem - If we start with a dose of 100mg, k1 of .25/hour and a step size of .1 hour, the amount of drug remaining is 97.5mg - Both the trapezoidal rule and the Euler's method have error rates that put a limit to both methods, but it's an additional way to understand the concepts of drug absorption and elimination Careers Epidemiology = study of patterns, causes, and rates of diseases.

- Models can be converted to equations that can be used to solve important values such as equilibrium constants in the study of the rates of diseases.

Ex: Models were used to control the SARS epidemic (severe acute respiratory syndrome). Careers Ecology = study of relationships between organisms and their environment

Actual Studies:

- Modeling population dynamics in the Taihu lake ecosystem

- Predation of flatworms on mosquito larvae in rice fields was used as a biological control of disease transmission (connects ecology, medicine, and pharmacokinetics)

- Effects of lion predation in competition with wild dogs on cheetah population in the Serengeti. Biomedical Engineering Biomedical Engineering = Using engineering principles and applying it to biology and medicine

- Epitomizes the class that we are proposing

- Implantable cardiac pacemakers, defibrillators, joint replacement implants, biomedical imaging, tissue engineered skin for grafting, and novel drug

delivery (way to treat chronic diseases) Interview with Dr. Yukna - Computational Chemist by profession and a physics and chemistry professor at Maryville University

- Such a course would be interdisciplinary because it combines biology, chemistry, and math skills to understand a combination of concepts

- Would allow you to use technology while learning Interview with Dr. Yukna - To be able to study scientific problems correctly, you have you to understand the math behind it

- A course like this should be team taught by a math faculty with input from a science faculty member

- More hands on, independent, and provide work skills

- Beneficial for those students enrolled in the 3-2 year program for Biomedical engineering (with WashU) THE END Works Cited www.boomer.org/c/p3/c02/c0209.html

www.boomer.org/c/p3/c02/c0206.html

www.boomer.org/c/p3/c02/c0210.html

www.boomer.org/c/p3/c02/c0207.html

Rheinlander, Kim, and Dorothy Wallace. "Calculus, Biology and Medicine: A Case Study in Quantitative Literacy for Science Students." Numeracy 4.1 (2011): 3.

http://www.pcte.edu.in/jper/issues/2010-dec-vol-1-issue-2/paper-2.pdf

www.engr.iupui.edu/bme/faq.shtml

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# Calculus Applicability to Science

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