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Technical Presentation

Transcript: Overview power train The objective of the drive train is providing to the driver more than the enough torque to the wheels from the engine to the wheels Overview The main component of the drive train *Engine *Transmission *Final drive MAX SPEED from 50-55 km/h that make us finishing the endurance race MAX TOURQE That provide the car the enough strength to climb a 60° incline. For the evaluation of the torque required to obtain the enough strength to climb the 60° incline we made a simple study case 1-The design must have a 2-good balance of lightness 3-Reliability 4-efficiency 5-compactness, 6-cost-effectiveness CAD MODEL FOR CAR *Maximum Vehicle Dimensions: Width: 162 cm (64 in) at the widest point with the wheels pointing forward at static ride height. Length: Unrestricted *Terrain Capability: The vehicle must be capable of safe operation over rough land terrain including obstructions such as rocks, sand jumps, logs, steep inclines, mud and shallow water in any or all combinations and in any type of weather including rain, snow and ice. *The design subject: single-seat, all-terrain, sporting vehicle whose structure contains the driver. *Vehicle Configuration: The vehicle must have four (4) or more wheels not in a straight line. The vehicle may only use one Briggs & Stratton engine. The vehicle must be capable of carrying one (1) person 190cm (75 in) tall weighing 113kg Overview Overview Power train group Target Transaxle FINAL PRODUCT Overview ANALYSIS FONTS Technical Presentation Engine Engine Specifications The total reduction All vehicles are powered by one of the four Briggs & Stratton with 10HP power. OBJECTIVE OF DRIVETRAIN Transmission The requirements of the design

Technical Presentation

Transcript: Another option to diagnosing a check engine light is doing it yourself.With today's technology and resources anyone can diagnose a check engine light themselves. Why do check engine lights come on? Today's car are equipped with on board computers that monitor sensors and electrical connections when the computer senses something wrong it turns on the engine light to warn you about it. On-board computer senses a problem. Computer stores code and turns on engine light to warn you. Code scanner is plugged into cars data link. Code is retrieved and you can begin to identify the source of the problem. To diagnose a check engine light you have plug in a code scanner to the vehicle data link connection. When this is done the code scanner will retrieve any codes the compute has saved and then you can begin to identify the source of the check engine light problem. In order to diagnose a check engine light you are going to need a code scanner.What is a code scanner? A code scanner is a device that plugs in your vehicle and retrieves codes sent by the on board computer. Self Diagnosing Reason's engine light comes on Bad Sensor Bad Connection Engine Misfire Loose Fuel Cap There are different ways you can go about diagnosing a check engine light. When the on board computer sense something is wrong with the car it stores a code in the computer and turns on the check engine light to warn you about it. Ever since 1996 automakers were required to comply with OBD II which stands for On-board diagnostics which let the owner and technician diagnose the vehicle. Options for diagnosing engine lights Taking your vehicle to a dealership or independent shop are options for diagnosing your check engine light. But this can cost money and time. "How to Take Care of That Pesky Check Engine Light" Code Scanner Technical Presentation Codes/OBD II How to Take Care of That Pesky Check Engine Light Taking it to a dealership Going to an independent mechanic shop Doing it yourself Summary Dealerships/shops Diagnosing To summarize this presentation lets go over the processes again.

technical presentation

Transcript: Aggregate production Out lines Introduction (backround) The issue of the production in UAE Quarrying industry activities Environmental impact Air pollution Noise pollution Health hazard Guidelines for quarries Survey Conclusion Locations of current aggregate production in Fujairah Since Fujairah has the biggest portion stones excavation areas in the UAE , the city suffers from several health and environmental issues. these areas of stone crushing are close to residential areas which annoys people around. Transferring Loading & uploading of the prepared materials: Crushing and screening Air pollution Noise pollution Figure : dust coming out from quarries Figure : dust resulting from quarries While quarry blasting this is what happen before and after implementation. Techniques to control noise pollution Figure 2 Citizens opinions about affects of staying around the area. Figure 3 Citizens opinions about staying around the area or move Figure 4 Citizens believes on how much dust and noise will affect their lives. Blasting Air blast Ground vibration Stone crusher Truck traffic All drilling equipment will be fitted with an efficient dust collection system. Proper disposal arrangements to be made for the fine dust collected in bags or filters. All the drilling operators and supervising staff will adopt proper safety measures during drilling operations, includes wearing dust mask and ear plugs. Hours of operation: Drilling operations can be carried out round the clock. In case of complaints from the local residents living within 3 km from the quarry, the hours of operation can be restricted by the local competent authorities. All the drilling and ancillary equipment will be The municipality of Fujairah lately has done a survey from the residential areas around the excavation areas. This large scale survey was done for about 500 people and the results were as the following: Citizens knowledge about the stone crushing . Environmental impacts Health hazards Aggregate industry is growing at a fast pace all over the world since 2002 to meet the demand for the construction projects. For example, in UAE the aggregate industry created major negative environmental impacts, especially in the Northern and Eastern regions of UAE, where the quarries are distributed All stone and aggregate excavations and queries operations in the UAE shall comply with the guidelines for their day to day quarrying operations with respect to: drilling Blasting material handling in-site hauling transportation Major source of air pollution is “dust” Dust have physical effects on the surrounding plants Dust have chemical effects which affect long-term survival MOWE put standards for quarries Give fines Important Guidelines for Quarrying in UAE: - Introduction Quarrying involves activities that generate amounts of noise Mineral processing Exposing the mineral to be extracted Transport Aggregate industry process and results: - The issue of the production in uae Figure : respiratory illnesses Material Handling. Hauling in Site. Important Guidelines for Quarrying in UAE: - Drilling. Aggregate production in UAE is a very active and important process across the emirates and we specialize in our project the stone crushing in Fujairah city. Our study of the quarries negative impacts included two main parts the air and noise problems in addition to health problems. noise pollution is a serious issue bothering the nearby citizens. Several quarries processes caused this pollution such as blasting, air blast, ground vibration, stone crushers and truck traffic The second main problem is health hazards as a result of quarries work. This problem to be solved people should be aware and well taught since problems like sore eyes and throats are common to happen. It should be known that guidelines for quarries process must be followed otherwise problems in quarries work might happen Conclusion Figure : stone blasting Important Guidelines for Quarrying in UAE: - Sore eyes and throats hazardous place to live for those with respiratory illnesses Major source for asthma disease is from the dusts of aggregate excavation is (15% of asthmatic people in UAE) Fujairah case study To surround the area of stone crushing by trees (gardening the area) to prevent the spread of dust. To limit the time of stone crushing works. To not build any more houses near the area of quarries. To create new techniques to absorb the noise coming out from crushing the stone. Trying to eliminate the dust by creating new techniques to move down the dust before spreading to air. suggestions and solution Blasting. Air pollution Noise pollution Important Guidelines for Quarrying in UAE: - Quarrying activities which can cause noise pollution: Figure 1 Citizens knowledge about quarries In UAE, aggregate production is a major industry. Mountainous areas such as Fujairah, RAK and Ajman are major suppliers of aggregates and stones There are more than 100 quarries distributed in the northern eastern regions

Technical Background

Transcript: Abir Rahman - Technical Background Presentation 7/15/2020 Introduction Abir Ashfakur Rahman Ph.D. in Biomolecular Sciences Boise State University, Boise, Idaho Introduction Current affiliation: Tulane University School of Medicine, Bix Lab Current Postdoctoral work Postdoc work Novel therapeutics for ischemic stroke Tandem transient middle cerebral and common carotid artery occlusion (tMCAO) Occlude both the common carotid artery and the middle cerebral artery of mice at the same time, for one hour. In vivo Cell lines and procedures In vitro bEnd.3 cells - Mouse Brain Endothelial Cells - Procedure: 8-hour Oxygen-Glucose Deprivation and 18-24 hour reperfusion - Readouts: Western blot and Immunocytochemistry Primary Mouse Neural Stem Cells (Neurospheres) - Neurogenesis questions: - Stem cell proliferation - Neural differentiation - Neuroblast migration Primary microglia: Morphological characterization and proteomic profiling. bEnd.3 Neurospheres Neurospheres (adhered and cells migrating) Autophagy dysfunction as a mechanism of Parkinson's Disease Doctoral work The role of the VPS35 D620N mutation Autophagy Mechanism of cellular homeostasis - Protein turnover - Mitochondrial turnover - Endoplasmic reticulum turnover - Lipids turnover and more Autophagy Source: Novus Biologicals Measuring Autophagic Flux Measuring Autophagic Flux Source: Stress Marq Biosciences and Pieurucci et al. Neuropharmacology (2017) VPS35 D620N Originally identified by two independent studies in 2011 as a causal mutation. VPS35 Williams E.T., Chen X., and Moore D.J., Journal of Parkinson’s Disease (2017). VPS35 D620N inhibits autophagy Autophagy defect We showed that autophagic flux was reduced in VPS35 D620N mutant cells We used an overexpression construct, either overexpressing the WT allele, or the D620N mutant allele. Lentivirus mediated gene transduction Cell line generation For generating the WT and VPS35 D620N mutant transgenic cells, - We used Lentivirus to deliver the transgenes - HEK 293T cells were first transfected with viral component coding DNA, along with our transgenic construct, which also contained a puromycin resistance gene - The virus containing media was then collected and administered to SH-SY5Y cells - Cells were selected by puromycin treatment and validated via PCR and sequencing Source: Sigma-Aldrich Source: Elegheert et al. Nature Protocols (2018) CRISPR/Cas9 mediated mutagenesis - Used Origene kit and Synthego gRNA, to induce a G to A point mutation at base position 1858. CRISPR/Cas9 The transcriptome is altered in the VPS35 D620N mutant background ECM receptor interaction pathway Transcriptomic changes KEGG pathway analysis revealed potential altered pathways Akt signaling pathway Proposed pathway Hyaluronan Signaling High molecular weight HA inhibited autophagy HA and Autophagy CD 44 and HMMR expression altered in VPS35 D620N HA receptors Phosphorylation of AKT AKT Phosphorylation Other previous work Other work Confocal microscopy/ fluorescent microscopy: Took a course in bioimaging Worked as core facilities intern Worked with C. elegans and with D. melanogaster Team management: - trained and worked with many undergraduate students - taught lab sections of undergraduate courses - trained fellow postdoc and lab technician tissue culture and related in vitro work Acknowledgements Acknowledgements Members of the Bix Lab: Dr. I. Joachim Biose, Dr. Amruta Narayanappa, Mr. Kyle Esteves and Dr. Greg Bix. My thesis committee: Dr. Brad Morrison, Dr. Allan Albig, Dr. Julia Oxford and Dr. Matthew Ferguson BMOL Program Director: Dr. Denise Wingett and Program administrator: Beth Gee Dr. Bill Walthall, Dr. Ananias Escalanate Dr. Maria Andreina Pacheco Delgado and so many more. Thank You Comments?

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