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Transcript: British Medical Journal Annals of Rheumatoid Disease Synovial membrane inflamed and thickened. Bones and cartilage gradually begin to erode Stratification Change in MRI Erosion Score from baseline to week 24 with the use of Rituximab! Progression of osseous tissue formation, causing fusion of the bones, this reducing mobility and in resulting in pain Other Signs and Symptoms of RA Baseline MRI scan 14 days before 1st infusion. Images scored by 2 independent radiologists In fact, data presents joint improvement! All secondary outcomes lead to development of primary outcome (Joint erosion) van Elteren test Used to determine primary endpoint Percent change from baseline Study did not have true 'normal' Each patient's baseline was their individual 'normal' ANOVA cannot be used Test is considered inferior to others with a true 'normal' What if they're biologically naive? Randomized 1:1:1 Loss of energy Loss of appetite Low fever Dry eyes/mouth (sjorgren's syndrome) Rheumatoid nodules (elbows/hands) To evaluate the effect of Rituximab + MTX in reducing structural damage and joint inflammation vs. MTX alone in patients with active RA. Progression of RA 3. Fibrous Ankylosis MRI assessment of suppression of structural damage in patients with rheumatoid arthritis receiving rituximab: results from the randomised, placebo-controlled, double-blind RA-SCORE study Impact Factor: 10.38 Authors Professor Charles Peterfy MD, PhD 1. DiCarlo J. Julie Camille DiCarlo - Publications. Researchgatenet. 2015. Available at: http://www.researchgate.net/profile/Julie_Dicarlo2/publications. Accessed December 1, 2015. 2. Clinicaltrials.gov. A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate - Full Text View - ClinicalTrials.gov. 2015. Available at: https://clinicaltrials.gov/ct2/show/NCT00578305?term=00578305&rank=1. Accessed December 1, 2015. 3. Peterfy C, Emery P, Tak P et al. MRI assessment of suppression of structural damage in patients with rheumatoid arthritis receiving rituximab: results from the randomised, placebo-controlled, double-blind RA-SCORE study. Annals of the Rheumatic Diseases. 2014. doi:10.1136/annrheumdis-2014-206015. 4. Vimeo. MabThera (Rituximab) – Mode of action and the role of B cells in rheumatoid arthritis (RA) (1). 2014. Available at: https://vimeo.com/91432523. Accessed December 1, 2015. 5. Netter F, Iannotti J, Parker R. Musculoskeletal System. Philadelphia: Elsevier Saunders; 2013. Significant finding: Rituximab 1000 mg exhibited slower progression of joint erosion. Inclusion Criteria Study Objective American Rheumatology Criteria for ≥3 months and ≤10 years Erosion/signs/symptoms of synovitis in a single joint (MRI) IR to MTX at dose 12.5-25mg/wk ≥ 12wks More Analysis Interactive Voice Response System (IVRS) RA RA! Rituximab Against Rheumatoid Arthritis Discussion History of rheumatic autoimmune disease other than RA or significant systemic involvement secondary to RA Previously on another biologic agent that depletes B-cells. Progression of RA 2. Pannus Formation Founder and CEO of Spire Sciences. Attending radiologist at UCSF for 7 years Director of Arthritis Research for the Osteoporosis and Arthritis Research Group. Developed the WOMRS system and co-developed the RAMRIS (Rheumatoid Arthritis MRI Score) and PsAMRIS (Psoriatic Arthritis MRI Score) methods. - Spire Sciences’ mission is to improve world health by helping bring new and better therapies into clinical use faster. They are focused exclusively on central image analysis. <6 months MTX therapy ≥ 6 months MTX therapy +Bone erosion No bone erosion Primary Outcome Article Post-Hoc Analysis CARLOS TDS TIS week 12, 24, and 52 Health Assessment Questionaire Disability Index (HAQ-DI) Antibody to CD-20, which is found on the surface of B-cells Progression of RA 4. Bony Ankylosis Non-Biologic Hydroxychloroquine Sulfasalazine Leflunomide Methotrexate - Drug of Choice for non-biologic DMARDs Folate antimetabolite (anti-inflammatory and immunosuppressive) Most common type of autoimmune arthritis Progression of RA 1. Synovitis Statistical Analysis for Secondary Outcomes Efficacy Assessment Sponsors & Collaborators: Hoffmann-La Roche Rheumatoid Arthritis Symptoms Clinical significance: Rituximab+MTX prevents joint damage in MTX-IR patients with active RA Reductions in synovitis and osteitis --> reduction in erosion and cartilage loss. Will Rituximab slow the progression of joint erosion in patients with active RA, biologically naive, and failed MTX treatment? 75% of those affected are women Preparation Randomization Rheumatoid Arthritis (RA) Genant-Modified Sharp radiographic scoring Range is too narrow (0-4) Study only used biologically naive patients Possible author bias. He co-developed RAMRIS score Research facility focuses on Central Image Analysis Discrepancies between text, tables, and charts. Insignificant p-value in table, while chart and text indicate statistical significance.

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Transcript: VILLA AGNSAA-36 Villa house located around bole alem cinema with 500 m sq ground surface and 200 m sq living area. 2 bedroom, 2 bathroom 5 car parking space, guardhouse, generator, service quarters of 5 rooms kitchen area AGNSAA-44 Villa house located around bole behind Momona hotel with 600 m sq surface area, 2 bedroom, 3 bathroom AGNSAA-55 Villa house located around Somalia embassy with 700 m sq ground surface and 400 m sq living area. 2 bedroom, 2 bathroom 7 car parking space , 2 gates entrance, main house has living room with open kitchen 2 bath and 3 bedrooms service quarter with traditional kitchen 2 bath and 2 bedrooms G+ AGNSAA-41 G+2 house with basement of 2 rooms, ground surface of 475 m sq, living space of 300 m sq has a beautiful garden, with guardhouse and a 5 car parking space AGNSAA-46 G+1 house located around bole shalla. surface area 380 m sq. 4 bedroom and 2 bathrooms with service quarters and a guard house 4 car parking space. AGNSAA-54 G+1 house located around japan road, surface area of 400 m sq and 280 m sq living area Has about 5 car parking space, with a green area as well AGNSAA-59 G+1 house around bole Michael with surface area of 300 m sq and living area of 150 m sq G+1 house around bole Michael with surface area of 300 m sq and living area of 150 m sq Service quarters with 2 bedroom and a bathroom, main house with 4 bedroom and 2 bathrooms, 4 car parking space and a enjoyable garden AGNSAA-62 G+2 house around gerji, ministers road(behind the airport), 400 m sq surface area and 300 m sq of living area has about 4 car parking space a service quarter of a mini store, traditional kitchen and maid room with bath

Medical Test Presentation Template

Transcript: Presentation Headline Your subtitle text here About Your first slide content here About Us The good physician treats the disease; the great physician treats the patient who has the disease. Get to the main point of your Presesentation. Zoom in and present your content. Content Slides Topic Overview "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dodes eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in repre henderitas in voluptate. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in repre henderitas in voluptate." Explain your products or services Features List Private "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Mobile Friendly "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Statistics "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Innovative "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Time-Effective "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Well-Documented "This is example dummy text. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed dods eiusmo" Time Present important dates and events Timeline Slide Present important dates and events 1999 Present important dates and events 2002 Present important dates and events 2006 Present important dates and events 2020 Present important dates and events 2000 Present important dates and events 2004 Present important dates and events 2011 Present your charts and graphs Statistical Data Item 1 Item 2 Item 3 Item 4 Item 5 Item 6 Gallery Gallery Display more images here Add a short description of the image or project here. Image #1 Add a short description of the image or project here. Image #2 Add a short description of the image or project here. Image #3 Add a short description of the image or project here. Image #4 Add a short description of the image or project here. Image #5 Add a short description of the image or project here. Image #6 Add a short description of the image or project here. Image #7 Add a short description of the image or project here. Image #8 Use the world map to show locations Global Reach - Add details here - Add details here - Add details here - Add details here Staff Meet the Team Who are you? Gerardo M. Oliver This is an example dummy placeholder text area. Lorem ipsum dolor sit apisa kotiram ametis, cons iteecas tetureu adipiscing elit sed quia, Karla J. Walsh This is an example dummy placeholder text area. Lorem ipsum dolor sit apisa kotiram ametis, cons iteecas tetureu adipiscing elit sed quia, Bradley Sherman This is an example dummy placeholder text area. Lorem ipsum dolor sit apisa kotiram ametis, cons iteecas tetureu adipiscing elit sed quia, Sue E. Marquez This is an example dummy placeholder text area. Lorem ipsum dolor sit apisa kotiram ametis, cons iteecas tetureu adipiscing elit sed quia, Contact Details How can People Get in Touch with You? email@mail.com website.com fb.com/user.com lnked.in/user +1-202-555-0184 https://prezibase.com Get this Prezi Template from:

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