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Development of the Basal Ganglia and the Basal Forebrain

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mojgan hamdami

on 2 December 2018

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Transcript of Development of the Basal Ganglia and the Basal Forebrain

Over view of Neural development process
Development of the telencephalon
Basal Ganglia
Take Home Messages
Amygdala
Development of the Basal Ganglia and the Basal Forebrain
Brain mapping(ARTHUR W. TOGA ),Volum2,chapter:39

presented by: Mojgan Hamdami
M.Sc: Medical physiology@IUMS

Hamdami.m@tak.iums.ac.ir
Hamdami.mojgan@yahoo.com

Corpus Striatum
Amygdala
Neostriatum(striatum)
ventral
paleostriatum(paliidum)
Dorsal
ventral
dorsal
Basal Ganglia
S.innominata
S. nigra
Globus pallidus
Accumbance nucleus

Cudate
Putamen
Basal forebrain
Accumbance.n
Basalis.n
Diagonal band Broca
S.innominata
Medial Septal.n

located: front and below of Striatum
Forebrain
primery prosencephalon
Caudal Diencephalon(prosomer1-3)
Rostral Diencephalon
Telencephalon
Rostral secondary prosencephalon(prosomer4-6)
Optic vesicle
Preoptic region
Subpallium
striatum
Pallidum
Diagonal Band/Basal Forebrain
Preoptic Area
The output of the Basal Ganglia
V-A Thalamic.n
V-L Thalamic.n
C-M Thalamic.n
Habenula
PPT.n
S.colliculus

ventral GP
Basal.n of meynert (cholinergic input to cerebral cortex)
include:
V striatopallidal complex
Septal.n
Ot
Magnocellular basal forebrain system
Bed.n
Extended amygdala
S.innominate
Thick basal part(subpallium)
Thin part(pallium)
pallium
subpallium
Preoptic region

Lamina terminalis
Dorsal
Commissural plate
M-L elevations
GE or VE
LGE
MGE
Globus Pallidus
Basal.n of Meynert
part of wall of the V3
Caudate.n
Putamen
Pallium
LGE
MGE
GABAergic inter neurons of cortex
GE & ME
GABAergic neurons for the thalamic association.n
CGE
*POA

*Major fiber budles(to and from the telencephalon)
commissural plate
Basal Ganglia & amygdal
Caudal ganglionic eminence
Lateral ganglionic eminenc
Medial ganglionic emninence
Ganglionic Eminences
subpallium amygdal
rostral
intermediate
caudal
OT
Accumbance
Cd-P
Subpallial amygdal
Globus pallidus
Basalis.n Meynert
Bed.n of stria terminalis
large-celled(GP,Si,c-p,..)
arise early
medium and small sized(BF,..)
longer period
Cd-P
caudorostral
spatiotemporal Gradient
subthalamus
subthalamus.n
internal external GP
caudorostral arrangment
transverse
in rodents:
neurons of SN
E13-E15
R-DL to C-VM
extended
Ventral tegmental area(VTA)
E14-E16
pallial
subpallial
basolateral&associated cortical amygdala
amygdaloid.n
Basolateral amygdala
medial amygdala
central amygdala
CMA
continum with the bed.n of the striaterminalis
Extended amygdala
Time of neuron origin data Amygdala
in rodents: rostrocaudal gradient
early -arising structures(E13-E15/E17)
later-born(E14/E15-E16/E17)nuclei
5-6 gestational months:
inferior Amg
cell-dence columns(VP)
Ganglionic eminence
8gestational months:
high degree of maturity
Axonal projection
oldest nigral neurons
(generated before E15)
dorsolateral part
younger neurons
ventromedial part
(born after E15)
In rhesus monkeys with a gestation time of 160–170 days
substantia nigra neurons are generated between E36 and E43 with a peak around E38–E40
human mesencephalic dopaminergic cells was studied:
1)histofluorescence (1973)
2) tyrosine hydroxylase (TH) immunohistochemistry (2001)
SN neurons was found as early as stages 15–16,
3–4-month-old fetuses (10–15 cm crown–rump length):
catecholaminergic cell groups and nigrostriatal pathways are already richly developed and innervate abundantly the basal ganglia and olfactory region
*Each part of BG/BF has different gene expression, specification and differentiation.
*Different time origin in each part development.
*There is caudorostral spatiotemporal gradient in development of BG.
Full transcript