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apicomplexa lecture

a guest lecture in protistology class at UBC 2013

Noriko Okamoto

on 2 April 2013

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Transcript of apicomplexa lecture

The mechanism of erythrocyte invasion by the malarial parasite, Plasmodium falciparum Farrow et al (2011) Seminars in Cell Developmental Biology. 22(9):953-60 http://dx.doi.org/10.1016/j.semcdb.2011.09.022 Apicomplexa Dinoflagellates Colpodelids Chromerids Gregarines Sporozoans Perkinsids Syndinians Dinokaryotes Myzozoa Ciliates Alveolata Inner
Complex (IMC) Apical
Complex (AC) © The Author 2008. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org Gould S B et al. Mol Biol Evol 2008;25:1219-1230 Alveolins localize to the cortical regions of alveolate cells. Figure 3. The Flexibility of Apicomplexan Cell Division Striepen et al (2007) PLoS Pathog 3(6): e78.
http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030078 Figure 4. The Mechanics of Apicomplexan Mitosis and Budding Babesia Toxoplasma Eimeria Plasmodium
(malaria) www.zoology.ubc.ca/courses/bio332/labs/apiprofect/greg/gregarin.htm Monocystis Mitosis Life cycle Apicoplast Parasite's relic plastid
non photosynthetic
essential to parasites' survival Biology of the Cell (2007) 98, 535-545
www.biolcell.org Figure 2 Structure of the apicoplast and variation in size and shape of the protuberances Include Human and Livestock/poultry pathogens claimed about 655,000 lives in 2010

put about 3.3 billion people, half the world population, at risk parasites of various invertebrates
infecting intestines/coeloms/
reproductive vesicles Selenidium terebellae movement Selenidium vivax movement Lecudina sp. gliding Pterospora schizosoma
dynamic peristalsis-like movements Selenidium vivax
dynamic peristasis-like movements © Brian S. Leander Large cell
Epicellular parasites
Attatch to the host tissue on the anterior end mirotubules Syzygy
= pairing up Trophozoite Fertilization Meiosis Gametogenesis Gametocytogenesis Fertilization Meiosis Fertilization Meiosis Gametogenesis Gametocyto-
genesis Fertilization Meiosis Gametogenesis Gametocytogenesis Merogony Merogony Merogony Fertilization Meiosis Gametogenesis Gametocyto-
genesis Merogony Fertilization Meiosis Gameto-
genesis Gametocyto-
genesis Schizogony Schizogony ideal drug target Free living grazors
feeding with the apical complex Parasites of shellfish or algae
invade with the apical complex Coral symbionts
missing link between the dinoflagellate plastid and the apicoplast

Swimming cell has the apical complex Perkins 1976 Structural support
Locomotion Structural components
conoid - microtubular*
polar rings
Secretory organelles
Micronemes - secretion to the parasite's plasma membrane
Rhoptries - secretion to the host cell Dino Api "Budding" inside the mother cell
often palintomic Origin? Peridinin-type plastid
= red algal origin Parasites Parasites Grazors Parasites Parasites Photosynthetic/
Parasites Photosynthetic
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