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8.2 Structure of DNA

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Katelynn Dorn

on 18 November 2016

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Transcript of 8.2 Structure of DNA

Watson and Crick's 3D DNA Model
Linus Pauling had found that proteins could be helical (spiral)
James Watson and Francis Crick
How Does Deoxyribose Differ From Other Sugars?
glucose- C6H12O6
deoxyribose- C5H10O4
Nucleotides Always Pair in the Same Way
the sugars and phosphates on a nucleotide make up the backbone, with the bases in the middle
The bonds between bases are hydrogen bonds
Base-Pairing Rules
thymine (T) always pairs with adenine (A)
guanine (G) always pairs with cytosine (C)
the 2 strands of DNA are always complementary to each other
Erwin Chargaff found the amount of A=T and C=G
8.2 Structure of DNA
X-Ray Evidence
Rosalind Franklin and Maurice Wilkins studied DNA with x-ray crystallography
patterns suggested that DNA was a double helix
The Double Helix
Watson and Crick's first models suggested that A paired with A, C paired with C, and so on.
Discovered if they paired double-ringed nucleotides with single-ringed ones, they fit like a puzzle
DNA is a double helix
DNA is Composed of 4 Types of Nucleotides
DNA is a polymer
nucleotide
a phosphate group (phosphorus w/ 4 oxygens)
ring-shaped sugar: deoxyribose
nitrogen base (single or double carbon ring w/ nitrogen)
DNA Base Pairs
One molecule of human DNA contains billions of nucleotides
Purine
Adenine (A)- double ring
Guanine (G)- double ring
Pyrimidine
Cytosine (C)- single ring
Thymine (T)- single ring
How are the four DNA bases similar to each other? How are they different?
How did the Watson and Crick model explain Chargaff's rule?
What sequence of bases would pair with TGACTA?
Which base pairs do you think are held together more tightly? Why?
Full transcript