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Inflammation

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by

Jennifer Thankachan

on 21 March 2016

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Transcript of Inflammation

Treatment of Inflammation
ice & rest for mild inflammation
drugs for everything else
antipyretics
NSAIDs
corticosteroids
Antipyretic Drugs
aspirin (ASA)
ibuprofen
NSAID
acetaminophen
not an NSAID, but a COX inhibitor
Antipyretics
work to decrease core body temperature by communicating with the hypothalamus and dilating blood vessels to allow body heat to dissipate
Inflammation
Process of Inflammation
1. cellular injury
2. mast cells release chemicals, chiefly histamine
(histamine interacts with 2 different receptor sites:
-H1 (vasculature)
-H2 (stomach)
3. INFLAMMATION OCCURS
*edema
*erythema
*pain
*warmth
NSAIDs
*all are analgesics & antipyretics
Jennifer Thankachan, RN, MSN
*all of these antipyretics are also analgesics
ibuprofen:
works by inhibiting synthesis of prostaglandins (by blocking COX, the enzyme involved in making prostaglandins)
AE: nausea, heartburn, epigastric pain
Cyclooxygenase
COX 1: affects platelet aggregation
COX 2: promotes inflammation
celebrex inhibits only COX 2

**ASA inhibits both

aspirin
classified as a salicylate
AE: GI upset/bleeding
*potential for toxicity, s/s include tinnitus, HA, excessive sweating, dizziness (dosing should not exceed 4 g/day)
Corticosteroids
cortisol is a natural steroid hormone produced in the adrenals (aka, glucocorticoids)
corticosteroid drugs suppress histamine & prostaglandins
*because of this, they also suppress adrenal gland function
prednisone is the prototype drug
prednisone
classified as a corticosteroid
used short-term for treatment of severe inflammation
AE: Cushing Syndrome
*do not discontinue this drug suddenly
Nursing
Considerations
Full transcript