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Mitochondrial proton gradient and uncoupling protein in brow

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Tanjot Singh

on 6 October 2014

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Transcript of Mitochondrial proton gradient and uncoupling protein in brow

Mitochondrial proton gradient and uncoupling protein in brown fat
UCP-1 and Oxidative Stress
Reactive oxygen species are byproducts of the electron transport chain
Reactive oxygen specie overproduction leads to oxidative stress

What are UCPs?
- Located between ATP synthase
and the rest of the ETC
- Ion channel for hydrogen ions
- Dissipates the proton gradient
- RESULT = less ATP produced

Important in:
1) Energy balance
2) Oxidative stress control
3) Thermal homeostasis

**Our topic refers to Brown Adipose
Tissue (BAT), so UCP1 will be focused on**
Mitochondrial proton gradient and
uncoupling protein in brown fat

Noor El-Dassouki, Tanjot Singh, David Di Iorio, Michelle Lung
- UCP -> lowers production rate of ATP

- This doesn't mean these proteins are bad for you!
(Instead, it helps balance energy and heat)

- Some parts of the body focus on ATP production while others focus on heat production (E.g. brown fat)

Brown fat displays increased activity in the cold-acclimated state
Increased proton electrochemical gradient corresponds to a decreased rate of heat production
Enzyme activity determines respiration rate
Norepinephrine Causes UCP-1
What is norepinephrine?
A hormone that controls our attention and responses
Noradrenergic refers to the areas of the body that produce or are affected by norepinephrine
What does it effect?
Production of uncoupling protein called thermogenin
Production of ATP

Oxidative stress is an unavoidable consequence of being in an aerobic environment
→When UCP 1 is present the production of ATP decreases
→When UCP 1 isn’t present ROS increase, so there is more oxidative stress
This is why it is important to have UCP 1
Full transcript