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Hilary Stebbins

on 27 November 2017

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Transcript of Zoloft

- Sertraline -

Selective Serotonin Reuptake Inhibitors:

Serotonin is one of the neurotransmitters that carry signals between brain cells. SSRIs block the reuptake of serotonin in the brain, making more serotonin available to the receptors within the brain to synapse more easily. SSRIs are considered selective by nature because they seem to primarily affect serotonin alone
Route of Administration
How the drug enters the body
Typically, the prescribed route of administration is Oral, in the form of pills or capsules. The drug Zoloft can have different dosages prescribed and are available in different dose pill/capsules.
Resources used in researching Zoloft
Zoloft Brand website: ww.zoloft.com

National Alliance on Mental Illness: https://www.nami.org/Learn-More/Treatment/Mental-Health-Medications/Sertraline-(Zoloft)



U.S. National Library of Medicine: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0012108/

FDA: https://www.fda.gov/ohrms/dockets/ac/04/briefing/4006b1_06_zoloft-label.pd

Company clinical studies: https://www.pfizermedicalinformation.com/en-us/zoloft/clinical-studies

Most common Side Effects
Zoloft Overview
Sertraline, better known as its brand name of Zoloft is used mainly as an antidepressant medication. The approved usage includes disorders of major depressions, post-traumatic stress, prementral dysphoria, panic, anxiety and obession complusive disorders.
By Cassandra Deardorff
The factors that influence the bioavailablity of the drug
There are disadvantages you factor in when using the Oral Route. The factors of absorption, food in the stomach and first pass metabolism reduce concentration of the drug before said drug makes it into the blood system.
The advantages of the use of the oral route of administration is why this route is so commonly used. The drug can easily be self-administered painlessly. It is safe and convienent for the patients prescribed.
Distribution through the blood
blood circulates the drug to the target site: the brain
Using the oral route of administration, the drug begins at the mouth, digested into the stomach and liver, through the GI tract, and the remaining drug is absorbed into the blood stream.
Through the blood stream, Zoloft is absorbed and passes the blood brain barrier. Once inside the brain itself, the drug can truly begin its purposed use. In this case, the Zoloft begins to block the reuptake of Serotonin Receptors.
Other Pharmacokinetic factors
Zoloft has a half life range between 22-36 hours and daily administration is found to be effective. It has unlikely inhibition effects on CYP450 enzymes and few drug-drug interactions.
Sexual Dysfunction
Dry mouth
Full transcript