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Transcript of Prion
Source: Dr. Fred Cohen, UCSF http://www.cdc.gov/ncidod/dvrd/prions/ http://brain.oxfordjournals.org/content/128/9/2026.full http://brain.oxfordjournals.org/content/132/10/2669.full http://www.fsis.usda.gov/factsheets/Bovine_Spongiform_Encephalopathy_Mad_Cow_Disease/index.asp Other Prion Diseases. Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. In the early stages of disease, people may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur. http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm Kuru is a rare and fatal brain disorder, which was the result of the practice of ritualistic cannibalism (of where relatives prepared and consumed the tissues, including brain of deceased family members.) Brain tissue from individuals with kuru was highly infectious, and the disease was transmitted either through eating or by contact with open sores or wounds. Government discouragement of the practice of cannibalism led to a continuing decline in the disease, which has now mostly disappeared. http://www.ninds.nih.gov/disorders/kuru/kuru.htm Scrapie is a disease of sheep and goats that destroys their brains. The disease came from Great Britain in 1947. It kills the brain cells of sheep so that they can not get up to eat and drink. Animals that have scrapie will rub against things and scrape off their wool or hair. This scraping by the animals is what led to the naming of the disease. Currently there is no cure for scrapie There is no true use of prions in medicine because it is found normally in the body or can be very harmful in the wrong form. But studies do show that prions expressions on stem cells is necessary for the body's renewal of bone marrow Use of prions in medicine http://peds.oxfordjournals.org/content/13/2/99.full Normal prions are pivotal in memory processing and have a major role in the nervous system. Studies shows a defficiency in PrP in the brain may lead to decreased motor coordination as one ages. prions are transmitted by ingestion of infected meats or from environmental deposits from dead animals and urine.