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Alzheimer's Disease vs Mild Cognitive Impairment: What Human Eye doesn't see.

SPM5 to obtain Probabilistic Gray & White Matter Maps & determine Brain Atrophy in Alzheimer's Disease.

Ruth Martín Boizas

on 4 October 2013

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Transcript of Alzheimer's Disease vs Mild Cognitive Impairment: What Human Eye doesn't see.

Alzheimer's Disease vs
Mild Cognitive Impairment:
What Human Eye doesn't see

Ruth Martín Boizas M.D. Radiologist
Music by Droela at Soundcloud "Rompeolas"
Hospital Universitario de Getafe
Madrid. Spain.
to analyze
MRI protocol for Mild Cognitive Impairment
to obtain multiplanar visualization
Coronal GE T2
to look for subtle hemorrhages
MRI convert
Transforming DICOM to analyzable images (HDR)
Centered in Anterior White Commissure
Space-Normalizing using MRIcro
Decalped images
MRI cro
Parametric Mapping
Semiautomatic Segmentation using SPM5
Realign + Reslice + Estimate
Parametric Mapping
Talairach Coordinates
Gray & White Matter Templates
Measurable Gray & White Matter Probabilistic Maps
Segmentation + Bias Correction + Warping
Measurable & Comparable Warped Images
Gray Matter

447.7 mL
White Matter


442.26 mL

782.13 mL
Total Volume

Measurable & Comparable Real Volumes
Does our human & experienced Radiologist Eye see
"brain atrophy"
on rutinary CT or MRI images?
If answer is "Yes" our Neurologists or Geriatricians decide to treat the patient medically
If answer is "No" or "Not sure" we continue with a specific MRI study & Postprocessing Structural Brain Mapping
We only consider selected patients clinically diagnosed of
Mild Cognitive Impairment
by Neurologists and/or Geriatricians & Neuropchycologists
Simple rutinary CT and/or MRI study?
MRI images with specific acquisition and complex long Postprocessing Parametric Mapping using Computer tools to avoid interobserver variability?
We can determine our patient's neuron loss evolution comparing to himself & to normal population
We diagnose and treat Alzheimer's Disease before Clinical or Traditional CT/MRI Evidence
Thank you!
VBM5 algoritm from Christian Gaser's Structural Brain Mapping Group
Full transcript