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Alzheimer's Disease vs Mild Cognitive Impairment: What Human Eye doesn't see.
Transcript of Alzheimer's Disease vs Mild Cognitive Impairment: What Human Eye doesn't see.
Mild Cognitive Impairment:
What Human Eye doesn't see
Ruth Martín Boizas M.D. Radiologist
Music by Droela at Soundcloud "Rompeolas"
Hospital Universitario de Getafe
MPRAGE 3D T1
MRI protocol for Mild Cognitive Impairment
TSE 3D SPACE T2
to obtain multiplanar visualization
Coronal GE T2
to look for subtle hemorrhages
Transforming DICOM to analyzable images (HDR)
Centered in Anterior White Commissure
Space-Normalizing using MRIcro
Semiautomatic Segmentation using SPM5
Realign + Reslice + Estimate
Gray & White Matter Templates
Measurable Gray & White Matter Probabilistic Maps
Segmentation + Bias Correction + Warping
ROIs & VOIs
Measurable & Comparable Warped Images
Measurable & Comparable Real Volumes
Does our human & experienced Radiologist Eye see
on rutinary CT or MRI images?
If answer is "Yes" our Neurologists or Geriatricians decide to treat the patient medically
If answer is "No" or "Not sure" we continue with a specific MRI study & Postprocessing Structural Brain Mapping
We only consider selected patients clinically diagnosed of
Mild Cognitive Impairment
by Neurologists and/or Geriatricians & Neuropchycologists
Simple rutinary CT and/or MRI study?
MRI images with specific acquisition and complex long Postprocessing Parametric Mapping using Computer tools to avoid interobserver variability?
We can determine our patient's neuron loss evolution comparing to himself & to normal population
We diagnose and treat Alzheimer's Disease before Clinical or Traditional CT/MRI Evidence
VBM5 algoritm from Christian Gaser's Structural Brain Mapping Group