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Copy of Muscle Contraction Project
Transcript of Copy of Muscle Contraction Project
- role of neurotransmitters
- how we can inhibit muscle
" Prior to intubation for a surgical procedure the anaesthetist administered a single dose of the neuromuscular blocking agent succinylcholine to a 23-year-old male to provide muscular relaxation during surgery and to facilitate the insertion of the endotracheal tube. Following this the inhalation anaesthetic was administered and the surgical procedure completed"
Normal Muscular Contraction
The Membrane of a Motor Neuron Axon
Sliding Filament Theory
Fibrils slide over each other, shortening the length of the sarcomere. This results in contraction of the muscle
Medical Pastiche, "Nailing your First Intubation, 2010, accessed on 09/04/13<http://1.bp.blogspot.com/_miFTpTj57Hg/TFtQUExfdxI/AAAAAAAABQI/7g50yUFFebw/s1600/intubation.jpg>
OkeBiologyInfo, "Action Potential", 2012, accessed on 09/04/13, <http://4.bp.blogspot.com/-b8S1c41K6Hk/TxeqeplM6II/AAAAAAAAAnA/thUIdMbwNz4/s1600/actionPotential.jpg>
Bailey Bio, "Sarcomere", accessed 09/04/13<http://www.baileybio.com/plogger/images/anatomy___physiology/05._powerpoint_-_muscular_system/sarcomere.jpg>
Van Putte, C, Regan, J, Russo, A. (2013). Muscular System. In: Seeley's Essentials of Anatomy and Physiology. 8th ed. New York: McGraw Hill. 150 - 191.
Antranic.Org, "Synaptic Transmission by Somatic Motor Neurons", 2012, accessed 09/04/13, <http://antranik.org/wp-content/uploads/2012/04/synapse.jpg>
Reece, J, Meyers, N, Urry, L, Cain, M, Wasserman, S, Minorsky, P, Jackson, R, Cooke, B. (2012). The Chemical Context of Life. In: Campbell Biology, Australian Version. 9th ed. Canberra: Pearson. 30-68.
Thanks for Listening
Would anyone like to ask a Question?
A depolarising neuromuscular blocker
ACh is hydrolised by acetylcholinesterase,
preventing accumulation in the neuromus-
How else can we inhibit
Anything affecting the:
-binding ability to receptors
e.g. Curare - a substance used by native
South Americans on arrow heads to induce
- prevents the membrane from repolarising
- maintains the membrane potential above the threshold
- its breakdown by enzymes is slower than the breakdown of ACh by acetylcholinesterase
How does succinylcholine work?
Ehow, "Uses of Enzymes", accessed on 09/04/13,<http://www.ehow.com/about_4793719_uses-of-enzymes.html>
- prevents repolarisation of the post synaptic fibre
- inhibits muscle contraction
- Vocal chords and trachea muscles relax
- Alows for succesfull intubation of patient
Jonas Appiah-Ankam and Jennifer M Hunter
Pharmacology of neuromuscular blocking drugs
Contin Educ Anaesth Crit Care Pain (2004) 4(1): 2-7 doi:10.1093/bjaceaccp/mkh002