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Sea life - FINAL

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Transcript of Sea life - FINAL

Respiratory outcomes of late preterm infants born to mothers with preeclampsia
Yasser Soliman*, Belal Alshaikh*, Essa Alawad*, Amy Metcalfe,
Kamran Yusuf*
*Department of Pediatrics, Section of Neonatology, University of Calgary
Department of Obstetrics and Gynecology, University of Calgary

Background
Hypothesis
Late preterm infants of mothers with EOPE have higher rates of respiratory morbidity as compared to late preterm infants of mothers with LOPE or normotensive mothers.

Methods
Design
: Retrospective cohort study.

Primary outcome:
Respiratory morbidity defined as the need for CPAP and/or mechanical ventilation and/or nasal prong oxygen in the first twenty-four hours of life.

Secondary outcomes :
Small for gestational age (SGA) , length of hospital stay, RDS, TTN.


Conclusion
Infants of mothers with early onset preeclampsia have more respiratory morbidity and longer duration of hospital stay
Late preterm infants (34+0 and 36+6 weeks gestation) comprise 85% of all preterm births.

They are at risk of several neonatal morbidities, the most common of which is respiratory, with conditions like respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN).

In addition to prematurity, the contribution of maternal medical conditions morbidity in late preterm infants is being increasingly recognized.

Results
Thank You
Preeclampsia (PE) is a pregnancy specific disorder characterized a new onset of hypertension and proteinuria, multi-organ involvement, affecting 5-8% of all pregnancies worldwide. PE is major cause of maternal and neonatal mortality and morbidity worldwide.


Inclusion criteria
: Late preterm infants born to normotensive mothers and mothers with EOPE and LOPE.

Exclusion criteria
: Chromosomal and major congenital abnormalities, intrauterine infections(TORCH), pregestational and secondary hypertension due to renal, autoimmune or endocrine disorders.
Early onset PE(EOPE): before 34 weeks gestation.
Late onset PE(LOPE): from 34 weeks gestation and above.
Their effect on outcomes of late preterm infants is not well established.
Statistics

Kruskal-Wallis test, the χ2 and Fisher’s exact test were used as appropriate. Multivariable logistic regression was used to account for confounders.
p < 0.05 was considered significant.

Yasser Soliman*, Belal Alshaikh*, Essa Alawad*, Amy Metcalfe˜,
Kamran Yusuf*
*Department of Pediatrics, Section of Neonatology, University of Calgary
˜Department of Obstetrics and Gynecology, University of Calgary
Late preterm infants
Preeclampsia
Classification of PE
?
National Neonatal Transport Teams Survey, a Canadian Experience

MgSO4 and neurodevelopmental outcomes of PT <29 wks born to mothers with EOPE.
Full transcript