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Copy of Ayahuasca - Eduardo Gastelumendi

Presentation for the 9th Congress of the INA: Treating Neuropsychiatric Illness: A Multidisciplinary Effort
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on 5 February 2014

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Transcript of Copy of Ayahuasca - Eduardo Gastelumendi

Ayahuasca,
History, Ethics & Law
Science
What do we know about Ayahuasca so far??
Therapeutic Approach
Ritual gives meaning to experience,
Experience that gives meaning to life.
a new tool
for health & personal Integration

More connected, higher awareness
Ayahuasca-Assisted Therapy
Access to forgotten Memories
Project one's Future and consequences of choices
Body sensations, Insights & Visions
New Rituals

Traditional
use of Substances
LEGAL
& SAFE
Traditional Knowledge
Sacred
Shaman

Purge &
Visionary

Comunity:
Sense of
belonging, continuity.
Transcendental
experience
Fusion of Cultures
Globalization

SAFE
Risk &
Side Effects
Published
Research
Physiologic
Hypothesis
Biochemical
Hypothesis
Existential Hypothesis
Psychodynamic
Hypothesis
Eleusinian Mysteries






(1500 B.C.)
Peyote
Greece
Psylocybe

Recontextualizing Ayahuasca
Science:
innovative and conservative

Research
Economic
interests

another deep dive

Banisteriopsis caapi
AMAZON
Pharmacopeia

Christianism and Spiritualism
Afro - Brazilian Religions
AYAHUASCA RELIGIONS
Barquinha
Daime
UDV
No evidence
Particular Moment
Enough evidence?
Ayahuasca

beta-carboline alkaloids - MAOIs
Treatment
Raises global SEROTONIN levels,
Acts as AGONIST at particular 5-HT receptors
Stabilizes DOPAMINE levels by net effect on 5HT 1C, 5HT 2A, 5HT 2C
Addiction
Mesolimbic dopamine
pathway
(“Reward Pathway” )
Below reinforcement & above withdrawal
Psychotria viridis
Banisteriopsis caapi
1st
Effect:
DMT
On the Serotonin sistem,
act as a agonist at most
serotonin receptors:
5HT 2A
5HT 1A
5HT 2C
2nd Effect:
MAOI's
Increases Monoamine levels:
dopamine,
serotonin,
norepinephrine
3rd Effect:
hormone levels
Increased levels have been found within 120 minutes:
prolactin,
cortisol,
growth hormone
Hypothesis
to treat Addictions
Jordi Riba
The net effect of ayahuasca at dopaminergic neurons
Mind Body
Dopamine &
Synaptic Plasticity
Learning
& Addiction
Psychodynamic perspective

Visions as Dreams (unconscious meaning)
Insights
Cognitive + emotional integration
Visual outcome to conflicts
Improves decision - making.
Peak experience
4 basic dimensions of human existence:
Physical
Social
Psychological
Spiritual
Awareness of interconnectedness
coca
&
Composition
MAPS & NEIP
Biochemical Hypothesis
Thank you!
Bibliography:
Anderson, B. T. (2012). Ayahuasca as Antidepressant? Psychedelics and Styles of Reasoning in Psychiatry. [Article]. Anthropology of Consciousness, 23(1), 44- 59.
Anderson B. T., Labate B. C., Tupper K. W., Barbosa P. C. R., Grob C. S., Dawson A.(2012). Statement on ayahuasca. International Journal of Drug Policy 23, 173-175.
Bouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., et al. (2012). Personality, Psychopathology, Life Attitudes and Neuropsychological Performance among Ritual Users of Ayahuasca: A Longitudinal Study. [Article]. PLoS ONE, 7(8), 1-13.
Brierley, D. I., & Davidson, C. (2012). Developments in harmine pharmacology-- implications for ayahuasca use and drug-dependence treatment. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 39(2), 263-272.
Coutinho, T. (2013) A questão da legitimidade e da legalidade dos usos contemporâneos da ayahuasca: Um estudo de caso. NEIP. online
Dos Santos, R. G. (2013). Safety and Side Effects of Ayahuasca in Humans— An Overview Focusing on Developmental Toxicology. [Article]. Journal of Psychoactive Drugs, 45(1), 68-78.
Feeney, K., Labate, B. C. (2013). Religious Freedom and the Expansion of Ayahuasca Ceremonies in Europe, in Breaking Conventions: Essays on Psychedelic consciousness. Libro, UK.
Liester, M. B., Prickett J. I. (2012). Hypotheses Regarding the Mechanisms of Ayahuasca in the Treatment of Addictions. Journal of Psychoactive Drugs, 44 (3), 200–208, 2012
Labate B., de Rose Isabel, dos Santos, Rafael. 2008. Ayahuasca Religions: A Comprehensive Bibliography and Critical Essays. MAPS. Santa Cruz.
Riba, J. (2003). Human Pharmacology of Ayahuasca. Tesi Doctoral. Universidad Autonoma de Barcelona.
Thomas C., Lucas P., Capler N.R., Tupper K. W., Martin G. (2013). Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada. [Article]. Current Drug Abuse Reviws, 6(1), 30-42.
Tupper, K.W. (2008). The globalization of ayahuasca: Harm reduction or benefit maximization? International Journal of Drug Policy. 19(4), 297-303.

Scientific
TABOO
Takiwasi
Ayahuasca Academy
(Beatriz Labate)
Hoasca Project
Charles Grob
Sidarta
Ribeiro
L. F. Tófoli
IDEAA
Psychotria
viridis
Amazon
DMT
Existential experiences: death, love, personal responsibility
Eduardo Gastelumendi MD
Lima, Peru
9th Congress of the INA
Chicago, 2013
Full transcript