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Reverse Engineering Vaccines for a Modern Plague

Ten minute talk for skepticamp - nov 3, 2012

Nienke van Houten

on 1 November 2012

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Transcript of Reverse Engineering Vaccines for a Modern Plague

Reverse Engineering Vaccines for a Modern Plague Nienke E. van Houten, Ph.D.
November 3, 2012
Skepticamp 34 million people have it. A Global Pandemic What am I? WHY? NO CURE
NO VACCINE MUTATION! This Agent is insidious. It inserts its genome into your DNA and kills the immune cells that are instrumental in fighting it. Reverse Engineered Vaccines Seth Berkley
Founder, International AIDS Vaccine Initiative “As many times as HIV changes its clothes, it’s still wearing the same socks, and now our job is to make sure we get the body to really hate those socks.” Mutation leads to Immune Evasion Conserved Regions
Vaccine Targets Source: Meyerson et al., J Vis Exp.2011 HIV/AIDS Vaccine Harris, et al., PNAS. 2011 Walker and Burton. Curr Opin Immunol. 2010 Every day, every possible mutation occurs on the 10 Kb genome. HIV-1 neutralizing epitopes are vaccine targets. Mutations occur on the viral surface HIV virus expressing 'red' surface spike Antibodies are produced against 'red' spike. Antibodies neutralize virus. Virus is no longer infectious. HIV virus mutates to express 'yellow' spike. Antibodies against 'red' spike don't recognize 'yellow' spike. 'Yellow' virus evades antibodies, infects other cells and replicates. Antibodies recognize regions called 'epitopes' 300 new cases every hour, 7,000 per day. Killed 1.7 million in 2011. 30 million have died since the start of the pandemic. QUESTIONS?
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