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Vaccine

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Marootpong Pooam

on 15 October 2013

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Transcript of Vaccine

Vaccine
History
Method and Preparing
Application
Monoclonal Antibody
Phage Display technology
History
Bacteriophage
Phage display libraries
Phage display and Vaccine
History
George P Smith, in 1985
Bacteriophage
History
César Milstein & Georges Köhler
Method
Vaccine types
Vaccine components
Vaccine types
Vaccine components
Developing vaccine
Ideal vaccine
Introduction
Vaccine
Marootpong Pooam
Undergraduate student
Department of Biology, Faculty of Science
Naresuan University
What is Vaccine?
Edward Jenner
History of vaccine
Vaccine development
" A vaccine is a biological preparation that improves immunity to a particular disease. "
History of vaccine
Edward Jenner
"the father of immunology"
Who was the pioneer of smallpox vaccine.
Live-attenuated vaccines
" A vaccine created by reducing the virulence of a pathogen, but still keeping it viable for example chicken pox vaccine and Live attenuated influenza vaccine (H1N1). "
" is killed vaccine that consists of virus particles which are grown in culture and then killed using a method such as heat or chemical for examples are the influenza vaccine and hepatitis A vaccine. "
Inactivated vaccine
Toxoid vaccines
" are made from inactivated toxic compounds that cause illness rather than the micro-organism. "
Examples of toxoid-based vaccines include tetanus and diphtheria.
" do not contain live components of the pathogen. They differ from inactivated whole-cell vaccines, by containing only the antigenic parts of the pathogen. These parts are necessary to elicit a protective immune response. "
Subunit vaccines
Conjugated vaccine
" is certain bacteria have polysaccharide outer coats that are poorly immunogenic. By linking these outer coats to proteins (e.g. toxins), the immune system can be led to recognize the polysaccharide as if it were a protein antigen. This approach is used in the Haemophilus influenzae type B vaccine."
" is a technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immunological response. "
DNA vaccine
Live vector vaccine
" is a vaccine that uses a chemically weakened virus to transport pieces of the virus in order to stimulate an immune response. "
Active components
Suspending fluid
Preservative Antibiotic and Stabilizer
Adjuvant
Active components
"Antigen"
Suspending fluid
Such as Water Nacl and Serum protein
Preservative Antibiotic and Stabilizer
are used to prevent fungal and/or bacterial
contamination of vaccines, and are present in some but not all vaccines
Adjuvant
"enhance the immune response to a vaccine
such as aluminium hydroxide, aluminium phosphate and potassium aluminium sulphate."
Ideal vaccine
Safe with no or few side-effects
Easy and cheap to manufacture
Stable for storage/transport
Would stimulate life-long protection against all forms of the disease
How the vaccine work?
" for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies "
The Nobel Prize in Physiology or Medicine 1984
Monoclonal antibody and Hybridoma cells
HypoxanthineAminopterin Thymidine
Phage display libraries
Phage display and Vaccine
"demonstrated the display of peptides on filamentous phage by fusing the peptide of interest on to gene III of filamentous phage."
Application
Full transcript