Loading presentation...

Present Remotely

Send the link below via email or IM


Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.


Esomeprazole (Nexium)

No description

Lisa Levander

on 11 October 2013

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Esomeprazole (Nexium)

Medical Indications
Duodenal Ulcer
Gastroesophageal Reflux Disease (GERD)
Helicobacter Pylori Eradication
NSAID-induced ulcer prophylaxis
Zollinger-Ellison Syndrome

Drug Target
H+,K+ ATPase enzyme pump
also known as the proton pump

Last step in gastric acid production
While the parietal cell is inactivated, the H+,K+ ATPase are located on vesicles inside the cell.

When the stimulated by gastrin, histamine, or acetylcholine, these vesicles move to and fuse into the acid secretory canaliculus of parietal cell's plasma membrane.

Using ATP for energy, the pump exchanges extracellular potassium (native ligand) with hydrogen ions within the cell.
Binding Site
Alpha subunit of the H, K-ATPase

Forms a disulfide bond with a cysteine
Proton-pump Inhibitor (PPI)
Enzyme Inhibitor

***Acid Pump Antagonist (APA)--is referred to as this, but Dr. Garrison said not really relevant for us***
Esomeprazole. In: Clinical Pharmacology. Tampa, FL: Gold Standard. https://library1.unmc.edu/login?url=http://www.clinicalpharmacology-ip.com?id=852776.

Sachs G, Shin JM. Pharmacology of proton pump inhibitors. Los Angles California: Current Medicine Group LLC; 2008. 10.

Yan D, Hu Y, Li S, Cheng M. A model of 3D-structure of H+, K+-ATPase catalytic subunit derived by homology modeling. Acta Pharmacologics Sinica. 2004;25(4):474.
Alissa Stark
Erin Buse
Kai Zheng
Lisa Levander

Prodrug--becomes activated by pH--reaction produces a sulphenamide

Sulphenamide forms a covalent, disulfide bond with the sulfydryl group of a cysteine on the H+,K+ATPase

Binds irreversibly to H+,K+ATPase and inhibits hydrogen ion secretion into the gastric lumen

Lipophilic, weak base, is inactive at neutral pH

**optical isomer**
Full transcript