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Dolly the Sheep Project

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Mollie Phalen

on 13 May 2013

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Transcript of Dolly the Sheep Project

Dolly the Sheep The Effects of Cloning in the 20th Century:
Dolly The Sheep Sources http://www.apimages.com/Search.aspx?st=k&remem=x&entity=&kw=dolly+the+sheep&intv=None&shgroup=-10&sh=14 About Dolly Dolly was the first successful attempt at cloning a mammal About Dolly (Continued) She was cloned at the Roslin Institute in Scotland in early 1996 Dolly was born on July 5th, 1996 She was born like any other sheep except her cells were artificially planted into the egg of another sheep. More About Dolly She died in 2003 The Life and Death of Dolly the Sheep Dolly was born and cloned in the Roslin Institute in Edinburgh, Scotland She was studied through her entire life. She was given extra food and treats there and became overweight early in her life. In January of 2002 it was noted that she had started limping. A vet came and looked at her and diagnosed her with arthritis Another sheep that was there was diagnosed with sheep pulmonary adenomatosis Sheep Pulmonary Adenomatosis, or SPA for short, is a disease that causes tumors (often cancerous) in a sheep's chest. It is a terminal disease. Dolly had spent much time with the other sheep that had gotten SPA One of the stable-hands noticed that Dolly had started coughing They put Dolly under anesthesia to look for signs of it in her chest. The vet diagnosed her with lung cancer, caused by SPA, and, not wanting her to suffer, they overdosed the anesthesia and killed her. The Scientists Responsible for Dolly:
Keith Campbell and Ian Wilmut Keith Campbell Ian Wilmut Keith Campbell died at age 58, on October 5, 2012 He was born in Lucey, England in 1944. This picture of dolly the sheep is from AP images What is cloning? Cloning is the artificially making and exact copy of one's DNA. There are different types of cloning. Main ones are: Artificial Embryo Twinning
SCNT SCNT
(Somatic Cell Nuclear Transfer) Used in the cloning of Dolly It is the transfer of a nucleus of one cell into another Artificial Embryo Twinning It is copying the way that natural, identical twins are born Science Involved in Cloning Biology is the main science needed for it. Cloning happens in many places but, most cloning occurs in the Roslin Institute in Scotland (the place that Dolly was cloned) This image is from AP images  Cloning has made an enormous impact on the world today. It has changed the way that we think about the cells in our bodies. It could also potentially help battle many diseases. If allowed, it could make a large impact on the future. Controversy Surrounding Cloning Some people believe that the engineering of life does not belong in the hands of humans. Effects of Cloning It has taught us more about the cells in our own bodies. It can lead to medical advances in the future such as creating specific, needed organs to go into a body http://www.apimages.com/Search.aspx?st=k&remem=x&entity=&kw=dolly+the+sheep&intv=None&shgroup=-10&sh=14 Mollie Phalen
Pd. 7 29 different cells were implanted with the DNA that was used to clone Dolly, but Dolly was the only one to survive. When Dolly's chromosomes were examined they were found to be shorter than that of other sheep her age. They were the size of an old sheep's. He was born and he grew up in Birmingham, England He went to school to become a medical technician but, he left and pursued a career in biology. Continued Keith Campbell He got a doctorate at the University of Dundee, in Scotland He did a lot of work with the cycles of cells and was considered a "cell-cycle biologist". He came up with the method for cloning that was used on Dolly from this. Ian Wilmut He went to the University of Nottingham. •He got a job at the Roslin Institute in 1990. It was working on cloning with Ian Wilmut. She was named after the country singer Dolly Parton She was often visited by reporters Her arthritis was most likely caused by being overweight. Her stuffed body is at the National Museum in Scotland and a sweater made from her wool is in the London Science Museum When he died, he left his two daughters, Claire and Lauren and a grieving science community She was bred and gave birth to six lambs. He continued his schooling and got a Ph.D in genetic engineering at Darwin College in the University of Caimbridge He became part of the Roslin Institute and is still part of it. He continues to work on cloning today. Wilmut and Campbell cloned Dolly after Ian Wilmut hired Keith Campbell to work with him. After Dolly they made Polly in 1997. She was a sheep made from a cell with human genes.

The Process is:
Isolate a somatic cell (any cell other than a reproductive one)
Transfer the nucleus of that cell into the egg of a female organism of the same species
Then the cell is made to artificially go through meiosis.
It is implanted into a surrogate mother and she carries the egg and a clone is born Many people also believe that Dolly's short life was caused by her being a clone. This makes them skeptical of the level of safety in cloning. Cloning has also changed the fields of biology and medicine completely. It has given new avenues to take and has revolutionized both of the fields. For these reasons, cloning has been banned in many countries. Pictures: Dolly: Background: http://www.apimages.com/Search.aspx?st=k&remem=x&entity=&kw=dolly+the+sheep&intv=None&shgroup=-10&sh=14 AP Images: http://commons.wikimedia.org/wiki/File:Cultivated_grass_providing_rich_pasture_for_sheep_-_geograph.org.uk_-_1248090.jpg
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