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SFDP_ERCmeeting_MTA201709

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Eniko Kubinyi

on 3 December 2018

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Transcript of SFDP_ERCmeeting_MTA201709

Enikő Kubinyi
Thank you for your attention!
Vielen Dank für Ihre Aufmerksamkeit!

Senior Family Dog Project:
Lisa Wallis, PhD
Patricia Piotti, DVM, PhD
Borbála Turcsán, PhD
Sára Sándor, PhD
Kálmán Czeibert, DVM
Dóra Szabó
Ivaylo Iotchev
Kitti Tátrai
Zsófia Dobó
Anna Egerer
Zsófia Bognár
BSc & MSc students

European Research Council (680040), MTA Bolyai
Buksi (27) Sárrétudvari, Hungary; † 2017. 08. 26.
eniko.kubinyi@ttk.elte.hu
Partners:
Psychobiology Research Group, Institute of Cognitive Neuroscience and Psychology: Anna Kis, Anna Gergely, József Topál
MTA-ELTE Comparative Ethology Research Group: Márta Gácsi, Bence Ferdinandy, Tamás Faragó, Linda Gerencsér
ELTE Department of Ethology: Attila Andics, Rita Báji, Ádám Miklósi
ELTE Department of Genetics: Tibor Vellai, Balázs Egyed
ELTE Department of Physiology: Árpád Dobolyi
SE Institute of Anatomy
SE OVI Institute of Molecular Biology: Zsolt Rónai
Kaposvár University: Örs Petneházy

Cognitive ageing in dogs:
an interdisciplinary approach
Eötvös Loránd University, Department of Ethology, Budapest, Hungary
European Research Council
Starting Grant 680040
MR: ventriculomegaly, resting state fMRI
Sleep EEG
Canine Tissue and Brain Bank
body of euthanised pet dogs, donated by owners
<2-4 hs postmortem time: N>40
>4 hs postmortem time: N>80
dissection, -80C
RNA later
other
Spock lives further
Bluey, 1910-1939
Molnár
Owner questionnaire
Cognitive tests
DNA (+blood) samples for genetic analysis
Su et al 1998
Subsample of dogs from the Cognitive Battery
no difference in manipulative persistency, attention, cognitive bias, vocalisations, activity levels, or orientation towards the owner
ability to remember the location of food in the memory test declined
number of trials necessary to learn a discrimination and a reversal learning increased
latency to approach a novel object was higher
number of mistakes committed in a problem solving test also increased
--> predictive behavioural markers without pre training

Preliminary outcome of the Cognitive Battery
-with age:
physiotherapy
Preliminary data: relative delta power is decreased in both slow wave and REM sleep phases, similarly to humans
changes in sleep activity (difficulty in falling asleep, early-morning awakening, less time spent in deeper sleep, less total sleep time)
based on Kis et al 2016
sleep spindles
phasic bursts of thalamo-cortical activity
transient oscillations in the sigma range (2-14 Hz or 9-16 Hz)
automatic detections in the 9-16 Hz range are promising analogues of human spindles in terms of predicting learning performance and sex differences.
brain atlas
Neuro-imaging
Why do we need the body?
since May 2016
open for international collaborations
DNA
Questionnaire
Mini Mental Test (pilot phase)
N=1207
Wallis et al. in prep
bright side
Open questions


process of normal ageing (MMT)
breed differences (questionnaire)
general knowledge typically increases
calmness increases: <2.5, 2.5-4.8, 4.8-6.9, >6.9
reactivity decreases (family beagles)
olds more often dominant over youngs
Ageing
Cause of death for all breeds (N=15,881)

27% cancer
18% "old age"
11% cardiac
Purebred Dog Health Survey 2014, The Kennel Club
Wallis et al
in prep
Is death inevitable?
Why do we die?
"It is not in nature's best interest to perfectly repair our bodies. The main thing is to keep us reproductive as long as possible, and then let our bodies deteriorate."

Steven Austad
programmed and damage related factors:
methylation
telomere shortening
cell cycle regulation
DNA damage, oxidation
accumulation of cell waste (autophagy)
etc.
age-dependent increase of fMRI adaptation effect for processing speech
Interventions
medical
physiotherapy
cognitive
sterilization
calorie restriction

touch screen
training
Wallis et al. 2017
DISCRIMINATION LEARNING:
Old (>6 years): 5-55 visits, mean: 22
Young: 5-39 visits, mean: 11
1 dog in each pair was fed 25% less food than its pair-mate
median life span: 11.2 years
13.0 years
onset of chronic disease delayed
Take home message
ageing affects every organ
adapting is possible as long as the brain remains healthy
focus on healthy brain ageing
prevention
intervention
calorie restriction
physical exercises
brain training
- no "retirement" please!
Gábor et al. in prep
MR volumetry: 40-60% ventricular enlargement over a 4 year period (Gunde et al. in prep) . NO behav. change
Wallis et al. in prep Kubinyi et al. 2009
Turcsán et al., in prep.
Kubinyi et al., in prep.
Neilson et al. 2001
Canine Cognitive Dysfunction
Buksi
>15 million senior dogs in Europe
30-70% show signs of dementia-like cognitive dysfunction
welfare problem for both dog and human
model of human ageing
focus on healthy brain ageing
dogdementia.com
N=127 healthy adult family dogs
(M age = 8.33 years, range 3.0-14.5; F = 65, M = 62)
Open questions:
gut microbiome-cognition correlations
effects of interventions
EEG markers
IGF1?
Kealey et al. 2002
cell cycle
Sterilization is linked 13.8% longer life expectancy in males and 26.3% in females (N=70,574)

(! Methuselah dogs are usually intact)
Hoffman et al. 2013
increase quality of life:
"owners report being amazed to see how well their dogs were progressing, and at the enthusiasm of their dogs"
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