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Brucellosis (Undulant Fever)
Transcript of Brucellosis (Undulant Fever)
Brucellosis (Bang's Disease)
Antibiotics such as tetracyclines, rifampicin, and the aminoglycosides streptomycin and gentamicin are effective against Brucella bacteria. But the use of more than one antibiotic is needed for several weeks, because the bacteria incubate within cells. The main way of preventing brucellosis is by using fastidious hygiene in producing raw milk products, or by pasteurizing all milk that is to be ingested by humans, either in its unaltered form or as a derivate, such as cheese.
Under the name "Malta fever", the disease now called Brucellosis first came to the attention of British medical officers in the 1850's in Malta during the Crimean War. The causal relationship between organism and disease was first established in 1887 by Dr. David Bruce.
In 1897, Danish veterinarian Bernhard Bang isolated Brucella abortus as the agent; and the additional name "Bang's disease" was assigned.
Maltese doctor and archaeologist Sir Themistocles Zammit earned a knighthood for identifying unpasteurized milk as the major source of the pathogen in 1905, and it has since become known as Malta fever. In cattle, this disease, usually caused by B. abortus, is also known as "contagious abortion" and "infectious abortion".
Emphasis on muscular pain and sweating. The duration of the disease can vary from a few weeks to many months or even years. In the first stage of the disease, septicaemia occurs and leads to the classic triad of undulant fevers, sweating , and migratory arthralgia and myalgia (joint and muscle pain). Blood tests characteristically reveal leukopenia and anemia, show some elevation of AST and ALT, and demonstrate positive Bengal Rose and Huddleston reactions. Diagnosis of brucellosis relies on demonstration of the agent: blood cultures in tryptose broth, bone marrow cultures. The growth of brucellae is extremely slow (they can take up to two months to grow) and the culture poses a risk to laboratory personnel due to high infectivity of brucellae. Demonstration of antibodies against the agent either with the classic Huddleson, Wright, and/or Bengal Rose reactions, either with ELISA or the mercaptoethanol assay for IgM antibodies associated with chronic disease histologic evidence of granulomatous hepatitis on hepatic biopsy adiologic alterations in infected vertebrae and marked osteophytosis are suspicious of brucellic spondylitis.
With combination drug therapy, most people will recover in two to three weeks. Even widespread infections may be cured. Untreated the infection may progress and increase in severity and also affect new tissues. Although brucellosis can take a chronic form, with periods of illness alternating with periods of no symptoms, persistent illness lasting longer than two months may be due to a previously unsuspected underlying disease or a complication of the brucellosis.
Brucellosis can affect almost any part of your body, including your reproductive system, liver, heart and central nervous system. Chronic brucellosis may cause complications in just one organ or throughout your body. Brucellosis can cause infection of the hearts inner linings which is the most serious of all the risks and the leading cause of death of individuals with brucellosis. There is also inflammation of the spleen and liver and inflammation and infection of the testicles.
Body systems affected and how
I chose this disease because i wanted to learn about something new that I didn't know. And my moms a nurse and when i asked h about this disease she said shes never heard of it so i thought it would be cool to learn something she didnt know either.
Why I chose this Disease
A total of 2,648 individuals of outpatients distributed in seven areas/cities of Xinjiang region, including Urumqi, Yining, Aksu, Hotan, Kaxka, Koria and Turpan were registered. 1080 individuals (40.8%) were diagnosed as infected with brucellosis with ages ranging from 0 to 89 years old. In the 40-61 years-old group, the infection rate of brucellosis reached 16.7% (442 individuals) and significant difference was found between various age groups. In all suspected cases, the incidence of brucellosis in male, Uygur people and individuals with clinical symptoms was statistically higher than that in female, people of Han nationality and individuals without clinical symptoms.
Animals that possibly carry brucellosis
Graph showing how long which states have been free of brucellosis.