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Neurocircuitry underlying individual variation in mood disorder symptomology in youth

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Hilary Marusak

on 21 May 2014

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Transcript of Neurocircuitry underlying individual variation in mood disorder symptomology in youth

white matter integrity
Serotonin
5, 6, 7
Low Extraversion

1,2
Dopamine
3, 4
Neuropsychological Systems
Challenges:
disease comorbidity
heterogeneity
loss of power
20%
Neurocircuitry underlying individual variation in mood disorder symptomology in youth
Hilary Marusak

Major Depressive Disorder
Anxiety Disorder
NEGATIVE AFFECT
ANHEDONIA
Specific Aims
$50
$26
10th

Early affective dysregulation predicts adult pathology
Mood Disorders
HIGH ANHEDONIA
HIGH NEGATIVE AFFECT
LOW NEGATIVE
AFFECT
LOW ANHEDONIA
Participants
Anhedonia
Reward & Motivation System
Negative Affect
Emotion Processing Neural Circuitry
Hypothesis
identify how individual variation in and
relate to...
Aim 1
brain function
Aim 2
functional connectivity
Aim 3
white matter integrity
Aim 4
brain structure
Preliminary Data
side project: developing a reliable method for tracing the uncinate fasciculus
Dissertation Prospectus Meeting
November 20, 2013
3rd
1
3
2
2
3
Often emerge during childhood/adolescence

1

Personality Types
Neuromodulatory Systems
NEGATIVE AFFECT
ANHEDONIA
High Neuroticism

NEGATIVE AFFECT
ANHEDONIA
ANHEDONIA
Low Behavioral Activation
High Behavioral Inhibition
Empirical Support
1. Multi-site Developmental Neuroimaging

2. Advanced, Multi-Modal Techniques
Training Objectives
Big Data Neuroimaging
Combine Data From: WSU, Stanford, Pittsburgh
Moderate SRCD Conference
Multivariate Analyses
Functional Connectivity MRI
Diffusion Tensor Imaging Tractography
3. Clinical Proficiency
Weekly Psychiatry Grand Rounds
Clinical Rotation
Clinical Assessments
NEGATIVE AFFECT
Aim 1
brain function
Aim 2
functional connectivity
Aim 3
Aim 4
brain structure
Questions?
Suggestions?

Acknowledgments
Dissertation Committee
Mentor
Faculty Mentors
SCAN Lab
Dr. Moriah Thomason
Dr. Mark Greenwald
Dr. David Rosenberg
Dr. Richard Slatcher
Dr. Ian Gotlib (Stanford)
Dr. Christopher Monk (Michigan)
Dr. Erika Forbes (Pittsburgh)
Dr. Jeffrey Stanley
Dr. Gary Glover (Stanford)
Dr. Noa Ofen
Dr. Naftali Raz
Dr. Vaibhav Diwadkar

Significance
Innovation
Leading cause of disability worldwide
1
Start early in life
Inform early detection and intervention strategies
B
B
Neuropsychological Systems
Neuromodulatory Systems
1,2
1,2
1,2
2
Major Depressive Disorder
Anxiety Disorder
Healthy Comparison
Significance
Innovation
Leading cause of disability worldwide
Little evidence establishing link to neurobiology
1
Start early in life
Inform early detection and intervention strategies
Multi-modal neuroimaging approach
Drawing on 3 samples to achieve a wide range of developmental variation
Personality Types
Major Depressive Disorder
Anxiety Disorder
NEGATIVE AFFECT
ANHEDONIA
anhedonia
negative affect
Specific Aims
identify how individual variation in and
relate to...
anhedonia
negative affect
multivariate analyses:
examine interactions between large-scale
neural networks
1
ANHEDONIA
NEGATIVE AFFECT
NEGATIVE AFFECT
ANHEDONIA
HIGH ANHEDONIA
HIGH NEGATIVE AFFECT
LOW NEGATIVE
AFFECT
LOW ANHEDONIA
Full transcript