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Claravis: Isotretinoin

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by

Michelle Van Ness

on 25 March 2013

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Transcript of Claravis: Isotretinoin

Accutane:
Claravis By: Michelle Van Ness 3/20/13
Period: 7 Isotretinoin (Accutane): This is a drug that is used for severe cases of acne. It is a drug that not only gets clears the acne, but it gets rid of it all together. This is the box for accutane as you can see it is called Claravis on the box but the generic name is accutane. This part of the box is the outer part. In the box there are three slips with ten pills encased in each. This is the front of the box This is both of the sides of the box This is the back of the box And this is the top These are the slips inside: This is the front This is the back And this is the inside I picked this product because, my dermatologist prescribed the drug to me and I took it for 10 months, but I want to know what I actually put in my body. I would never do the research on my own so this was the perfect opportunity This is the slip in the box This is the front This is the back This is the inside MSDS RIGHT HERE http://pharmacycode.com/msds/Accutane Here's the list of ingredients: The main ingredient is Isotretinoin
There are other ingredients as well.
These are butylated hydroxyanisole, edetate disodium, gelatin, hydrogenated vegetable oil, polysorbate 80, titanium dioxide, white wax and vitamin E. Accutane has too many side effects but there are a few that are the most common. Now when you look at the link given it will seem like it is a horrible drug to take because of all the severe side effects but most of them are extremely rare. The most common ones are:
Sun-Sensitive Skin
Abnormal Peeling of Skin
Dry Skin
Nosebleed
Dry Eye
Dryness of the Nose
Dry Mouth
and the last common one but probably most severe out of any side effects is birth defects. If you are pregnant and on this drug your baby will have horrible birth defects. This is link has the rest of the side effects in it http://www.webmd.com/drugs/drug-6661-Accutane+Oral.aspx?drugid=6661&drugname=Accutane+Oral&pagenumber=6 Here are four ingredients that are in this product:
isotretinoin
hydrogenated vegetable oil
titanium dioxide
and polysorbate 80 The first ingredient is the main ingredient which is isotretinoin. This drug has been used since 1982 when the Food and Drug Administration. When people started to take this drug the FDA didn't know just how much it would work but now it is one of the most effective anti-acne drug in the world. The reason for this drug being used in accutane is that it reduces sebum production, influences comedogenesis, lowers surface and ductal P. acnes and has anti-inflammatory properties. In other words the main effect it has is it changes the pores in the skin to produce less oil in-turn allowing a build up of oil not to form This is Isotretinoin This is the formula C20 H28 O2 Hydrogenated Vegetable Oil It has a molecular wait of 300.44 HVO is an ingredient that is used in shortening or margarine. It is created when vegetable oil undergoes the hydrogenated process. This is when C2H4 has two Hydrogen's to it. Which creates C2H6. Which is also the formula for HVO. HVO was added to supply a little moisture without interfering with Isotretinoin. Since Isotretinoin is a drug that takes away moisture from your skin, the HVO puts some moisture in your skin so you don't become a chapped mess. The side effects of this include high blood pressure, high cholesterol and even cancer. Polysorbate 80 is the next ingredient on the list. This ingredient is a surfactant and is used in mostly skin cleansing products, skin fresheners, shampoo, and many many other products that are put on the skin. The reason that it is used in these products and in Accutane is because it is a surfactant and helps oil be dispersed in water instead of water being dispersed in oil. So it helps with the Hydrogenated vegetable oil. This the formula and the structure C32 H60 O10 The side effects of this chemical are as follows:
Heart problems
Tumor growth
Headaches and Dizziness
Infections
and Gastrointestinal Problems Also there are multiple allergic reactions such as:
Sneezing
coughing
swelling
wheezing
skin rashes
shortness of breath
itching
and pain. Titanium dioxide: This is a natural occurring element. The oxide for this is mined them later purified for use in products. The reason it is used in accutane is that is to make the whiteness in the drug be shown better and to absorb, reflect or disperse light so that the drug doesn't deteriorate. Formula:
TiO2 Structure: 79.87 is the weight There are side effects to this chemical as well such as
irritation of throat and nose when inhaled
when it is touched it may cause skin irritation and scratching
may cause cancer but it is rare Resources: Isotretinoin:
http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DermatologicandOphthalmicDrugsAdvisoryCommittee/UCM281374.pdf
http://www.newdruginfo.com/pharmacopeia/usp28/v28230/usp28nf23s0_m43635.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835909/
http://www.webmd.com/drugs/drug-6662-isotretinoin+oral.aspx?drugid=6662&drugname=isotretinoin+oral Hydrogenated vegetable oil:
http://www.druglib.com/druginfo/accutane/description_pharmacology/
http://www.urbancure.org/book/images/accutane.html
http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/Knowing-Your-Fats_UCM_305976_Article.jsp
http://www.scientificpsychic.com/fitness/fattyacids2.html Polysorbate 80:
http://www.cosmeticsinfo.org/ingredient_details.php?ingredient_id=460
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5281955
http://voices.yahoo.com/dangerous-food-additives-polysorbate-80-could-7546884.html
http://www.livestrong.com/article/262369-polysorbate-80-side-effects/ Titanium oxide:
http://www.cosmeticsinfo.org/HBI/21/
http://www.ccohs.ca/oshanswers/chemicals/chem_profiles/titanium_dioxide.html
http://www.newdruginfo.com/pharmacopeia/usp28/v28230/usp28nf23s0_m83730.htm
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=26042 THE END
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