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Targeted Therapy

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zeinab mohammed

on 15 February 2014

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Transcript of Targeted Therapy

Targeted Therapy
Zeinab Mohamed Abd Elwhab ,BCOP
Clinical Pharmacist-NCI
Targeted Therapy
Chemotherapy
Receptor Tyrosine Kinase ??
Types
Approx. 20
EGFR Family
Erb 1
BCR ABL
VEGF Family
Imatinib

Dasatinib
Nilotinib
Erlotinib
Gefitinib
Cetuximab
Panitumumab
Bevacizumab

TKIs
MKIs
Sorafenib

Sunitinib
EGFR
BCR ABL
NSCLC
NHL
CML
Labeled Use
VEGF
Avastin®
Colorectal Cancer
NSCLC
Glioblastoma
Anti CD 20
Rituxan®
Tarceva®
Pancreatic Cancer
NSCLC
Iressa®
Vectibix®
Refractory Metastatic
Colorectal Cancer
Erbitux®
metastatic
colorectal cancer
squamous cell cancer of the head and neck
MKIs
Nexavar®
advanced renal
cell cancer (RCC)
unresectable
hepatocellular
cancer (HCC)
Sutent®
GIST
RCC
PNET
Anti CD
Rituximab

Alemtuzumab

EGFR Erb 2
HER2neu

Trastuzumab
®
Pertuzumab
Herceptin®
HER-2 overexpressing
metastatic breast cancer
HER-2 overexpressing metastatic gastric
or gastroesophageal junction adenocarcinoma
(in patients who have not received
prior treatment)
Drug Interaction
CYP3A4 Inducers:
:GP PARCS

CYP3A4 Inhibitors :
SICKFACES.COM

Erlotinib,Gefitinib,Gleevec,Sprycel,Tasigyna,Sutent
Sorafenib,Votrient
,Lapatinib

WiITH

CYP3A4

Pazopanib

Lapatinib

Votrient
®
Tykerb
®
Advanced
RCC
STS
HER2 overexpressing
advanced or
metastatic breast
cancer
Rituximab®
NHL
CLL
Mabcampath
®
B-CLL
Ponatinib
Regorafenib
Bosutinib
Proteasome Inhibitors
Bortezomib
mTOR inhibitors
Everolimus
Temsirlomus
Full transcript